Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4(+) T cells allows complex functional analyses

CD4(+) T cells are central mediators of adaptive and innate immune responses and constitute a major reservoir for human immunodeficiency virus (HIV) in vivo. Detailed investigations of resting human CD4(+) T cells have been precluded by the absence of efficient approaches for genetic manipulation li...

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Detalles Bibliográficos
Autores principales: Albanese, Manuel, Ruhle, Adrian, Mittermaier, Jennifer, Mejías-Pérez, Ernesto, Gapp, Madeleine, Linder, Andreas, Schmacke, Niklas A., Hofmann, Katharina, Hennrich, Alexandru A., Levy, David N., Humpe, Andreas, Conzelmann, Karl-Klaus, Hornung, Veit, Fackler, Oliver T., Keppler, Oliver T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748193/
https://www.ncbi.nlm.nih.gov/pubmed/34949807
http://dx.doi.org/10.1038/s41592-021-01328-8

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