Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality, stress response activation, and cell viability u...

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Detalles Bibliográficos
Autores principales: van der Stel, Wanda, Yang, Huan, Vrijenhoek, Nanette G., Schimming, Johannes P., Callegaro, Giulia, Carta, Giada, Darici, Salihanur, Delp, Johannes, Forsby, Anna, White, Andrew, le Dévédec, Sylvia, Leist, Marcel, Jennings, Paul, Beltman, Joost B., van de Water, Bob, Danen, Erik H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748354/
https://www.ncbi.nlm.nih.gov/pubmed/34642769
http://dx.doi.org/10.1007/s00204-021-03160-7

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