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Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing

Compulsivity is a poorly understood transdiagnostic construct thought to underlie multiple disorders, including obsessive-compulsive disorder, addictions, and binge eating. Our current understanding of the causes of compulsive behavior remains primarily based on investigations into specific diagnost...

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Autores principales: Den Ouden, Lauren, Suo, Chao, Albertella, Lucy, Greenwood, Lisa-Marie, Lee, Rico S. C., Fontenelle, Leonardo F., Parkes, Linden, Tiego, Jeggan, Chamberlain, Samuel R., Richardson, Karyn, Segrave, Rebecca, Yücel, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748429/
https://www.ncbi.nlm.nih.gov/pubmed/35013101
http://dx.doi.org/10.1038/s41398-021-01773-1
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author Den Ouden, Lauren
Suo, Chao
Albertella, Lucy
Greenwood, Lisa-Marie
Lee, Rico S. C.
Fontenelle, Leonardo F.
Parkes, Linden
Tiego, Jeggan
Chamberlain, Samuel R.
Richardson, Karyn
Segrave, Rebecca
Yücel, Murat
author_facet Den Ouden, Lauren
Suo, Chao
Albertella, Lucy
Greenwood, Lisa-Marie
Lee, Rico S. C.
Fontenelle, Leonardo F.
Parkes, Linden
Tiego, Jeggan
Chamberlain, Samuel R.
Richardson, Karyn
Segrave, Rebecca
Yücel, Murat
author_sort Den Ouden, Lauren
collection PubMed
description Compulsivity is a poorly understood transdiagnostic construct thought to underlie multiple disorders, including obsessive-compulsive disorder, addictions, and binge eating. Our current understanding of the causes of compulsive behavior remains primarily based on investigations into specific diagnostic categories or findings relying on one or two laboratory measures to explain complex phenotypic variance. This proof-of-concept study drew on a heterogeneous sample of community-based individuals (N = 45; 18–45 years; 25 female) exhibiting compulsive behavioral patterns in alcohol use, eating, cleaning, checking, or symmetry. Data-driven statistical modeling of multidimensional markers was utilized to identify homogeneous subtypes that were independent of traditional clinical phenomenology. Markers were based on well-defined measures of affective processing and included psychological assessment of compulsivity, behavioral avoidance, and stress, neurocognitive assessment of reward vs. punishment learning, and biological assessment of the cortisol awakening response. The neurobiological validity of the subtypes was assessed using functional magnetic resonance imaging. Statistical modeling identified three stable, distinct subtypes of compulsivity and affective processing, which we labeled “Compulsive Non-Avoidant”, “Compulsive Reactive” and “Compulsive Stressed”. They differed meaningfully on validation measures of mood, intolerance of uncertainty, and urgency. Most importantly, subtypes captured neurobiological variance on amygdala-based resting-state functional connectivity, suggesting they were valid representations of underlying neurobiology and highlighting the relevance of emotion-related brain networks in compulsive behavior. Although independent larger samples are needed to confirm the stability of subtypes, these data offer an integrated understanding of how different systems may interact in compulsive behavior and provide new considerations for guiding tailored intervention decisions.
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spelling pubmed-87484292022-01-20 Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing Den Ouden, Lauren Suo, Chao Albertella, Lucy Greenwood, Lisa-Marie Lee, Rico S. C. Fontenelle, Leonardo F. Parkes, Linden Tiego, Jeggan Chamberlain, Samuel R. Richardson, Karyn Segrave, Rebecca Yücel, Murat Transl Psychiatry Article Compulsivity is a poorly understood transdiagnostic construct thought to underlie multiple disorders, including obsessive-compulsive disorder, addictions, and binge eating. Our current understanding of the causes of compulsive behavior remains primarily based on investigations into specific diagnostic categories or findings relying on one or two laboratory measures to explain complex phenotypic variance. This proof-of-concept study drew on a heterogeneous sample of community-based individuals (N = 45; 18–45 years; 25 female) exhibiting compulsive behavioral patterns in alcohol use, eating, cleaning, checking, or symmetry. Data-driven statistical modeling of multidimensional markers was utilized to identify homogeneous subtypes that were independent of traditional clinical phenomenology. Markers were based on well-defined measures of affective processing and included psychological assessment of compulsivity, behavioral avoidance, and stress, neurocognitive assessment of reward vs. punishment learning, and biological assessment of the cortisol awakening response. The neurobiological validity of the subtypes was assessed using functional magnetic resonance imaging. Statistical modeling identified three stable, distinct subtypes of compulsivity and affective processing, which we labeled “Compulsive Non-Avoidant”, “Compulsive Reactive” and “Compulsive Stressed”. They differed meaningfully on validation measures of mood, intolerance of uncertainty, and urgency. Most importantly, subtypes captured neurobiological variance on amygdala-based resting-state functional connectivity, suggesting they were valid representations of underlying neurobiology and highlighting the relevance of emotion-related brain networks in compulsive behavior. Although independent larger samples are needed to confirm the stability of subtypes, these data offer an integrated understanding of how different systems may interact in compulsive behavior and provide new considerations for guiding tailored intervention decisions. Nature Publishing Group UK 2022-01-10 /pmc/articles/PMC8748429/ /pubmed/35013101 http://dx.doi.org/10.1038/s41398-021-01773-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Den Ouden, Lauren
Suo, Chao
Albertella, Lucy
Greenwood, Lisa-Marie
Lee, Rico S. C.
Fontenelle, Leonardo F.
Parkes, Linden
Tiego, Jeggan
Chamberlain, Samuel R.
Richardson, Karyn
Segrave, Rebecca
Yücel, Murat
Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title_full Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title_fullStr Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title_full_unstemmed Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title_short Transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
title_sort transdiagnostic phenotypes of compulsive behavior and associations with psychological, cognitive, and neurobiological affective processing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748429/
https://www.ncbi.nlm.nih.gov/pubmed/35013101
http://dx.doi.org/10.1038/s41398-021-01773-1
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