A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

Antibodies binding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike have therapeutic promise, but emerging variants show the potential for virus escape. This emphasizes the need for therapeutic molecules with distinct and novel neutralization mechanisms. Here we describe the...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanke, Leo, Das, Hrishikesh, Sheward, Daniel J., Perez Vidakovics, Laura, Urgard, Egon, Moliner-Morro, Ainhoa, Kim, Changil, Karl, Vivien, Pankow, Alec, Smith, Natalie L., Porebski, Bartlomiej, Fernandez-Capetillo, Oscar, Sezgin, Erdinc, Pedersen, Gabriel K., Coquet, Jonathan M., Hällberg, B. Martin, Murrell, Ben, McInerney, Gerald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748511/
https://www.ncbi.nlm.nih.gov/pubmed/35013189
http://dx.doi.org/10.1038/s41467-021-27610-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748511/
https://www.ncbi.nlm.nih.gov/pubmed/35013189
http://dx.doi.org/10.1038/s41467-021-27610-z

Ejemplares similares