Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation

The applications of axially chiral benzonitriles and their derivatives remain mostly unexplored due to their synthetic difficulties. Here we disclose an unusual strategy for atroposelective access to benzonitriles via formation of the nitrile unit on biaryl scaffolds pre-installed with stereogenic a...

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Detalles Bibliográficos
Autores principales: Lv, Ya, Luo, Guoyong, Liu, Qian, Jin, Zhichao, Zhang, Xinglong, Chi, Yonggui Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748609/
https://www.ncbi.nlm.nih.gov/pubmed/35013312
http://dx.doi.org/10.1038/s41467-021-27813-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748609/
https://www.ncbi.nlm.nih.gov/pubmed/35013312
http://dx.doi.org/10.1038/s41467-021-27813-4

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