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PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis

The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator, modulates NLRP3 inflammasome in kidney injury. Primary renal tubular epithelial cells (RTECs) were isolated from C57BL/6 mi...

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Detalles Bibliográficos
Autores principales:	Nam, Bo Young, Jhee, Jong Hyun, Park, Jimin, Kim, Seonghun, Kim, Gyuri, Park, Jung Tak, Yoo, Tae-Hyun, Kang, Shin-Wook, Yu, Je-Wook, Han, Seung Hyeok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748677/ https://www.ncbi.nlm.nih.gov/pubmed/35013155 http://dx.doi.org/10.1038/s41419-021-04480-3

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