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EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation

Bladder cancer is a highly heterogeneous and aggressive malignancy with a poor prognosis. EGF/EGFR activation causes the detachment of SHC-binding protein 1 (SHCBP1) from SHC adapter protein 1 (SHC1), which subsequently translocates into the nucleus and promotes cancer development via multiple signa...

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Detalles Bibliográficos
Autores principales:	Yin, Hubin, Zhang, Chen, Wei, Zongjie, He, Weiyang, Xu, Ning, Xu, Yingjie, Li, Tinghao, Ren, Ke, Kuang, Youlin, Zhu, Xin, Yuan, Fangchao, Yu, Haitao, Gou, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748695/ https://www.ncbi.nlm.nih.gov/pubmed/35013128 http://dx.doi.org/10.1038/s41419-021-04479-w

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