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Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different peptides generate profound differences in G protein...

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Detalles Bibliográficos
Autores principales:	Deganutti, Giuseppe, Liang, Yi-Lynn, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J., Venugopal, Hari, Truong, Tin T., Glukhova, Alisa, Keller, Andrew N., Gregory, Karen J., Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A., Zhao, Peishen, Sexton, Patrick M., Wootten, Denise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748714/ https://www.ncbi.nlm.nih.gov/pubmed/35013280 http://dx.doi.org/10.1038/s41467-021-27760-0

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