PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice

Protein arginine methyltransferase 3 (PRMT3) is a co-activator of liver X receptor capable of selectively modulating hepatic triglyceride synthesis. Here we investigated whether pharmacological PRMT3 inhibition can diminish the hepatic steatosis extent and lower plasma lipid levels and atheroscleros...

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Detalles Bibliográficos
Autores principales: de Jong, Laura M., Zhang, Zhengzheng, den Hartog, Yvette, Sijsenaar, Timothy J. P., Martins Cardoso, Renata, Manson, Martijn L., Hankemeier, Thomas, Lindenburg, Peter W., Salvatori, Daniela C. F., Van Eck, Miranda, Hoekstra, Menno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748717/
https://www.ncbi.nlm.nih.gov/pubmed/35013582
http://dx.doi.org/10.1038/s41598-021-04524-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748717/
https://www.ncbi.nlm.nih.gov/pubmed/35013582
http://dx.doi.org/10.1038/s41598-021-04524-w

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