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Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major social and economic burdens; however, its underlying molecular mechanisms remain poorly defined. Here we show that the focal adhesion protein Kindlin-2 is highly expressed in the nucleus pulposus (NP), but no...

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Detalles Bibliográficos
Autores principales:	Chen, Sheng, Wu, Xiaohao, Lai, Yumei, Chen, Di, Bai, Xiaochun, Liu, Sheng, Wu, Yongchao, Chen, Mingjue, Lai, Yuxiao, Cao, Huiling, Shao, Zengwu, Xiao, Guozhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748798/ https://www.ncbi.nlm.nih.gov/pubmed/35013104 http://dx.doi.org/10.1038/s41413-021-00179-5

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