Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

Accumulation of misfolded proteins such as amyloid-β (Aβ), tau, and α-synuclein (α-Syn) in the brain leads to synaptic dysfunction, neuronal damage, and the onset of relevant neurodegenerative disorder/s. Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) are characterized by the aberrant...

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Detalles Bibliográficos
Autores principales: Kim, Changyoun, Hovakimyan, Armine, Zagorski, Karen, Antonyan, Tatevik, Petrushina, Irina, Davtyan, Hayk, Chailyan, Gor, Hasselmann, Jonathan, Iba, Michiyo, Adame, Anthony, Rockenstein, Edward, Szabo, Marcell, Blurton-Jones, Mathew, Cribbs, David H., Ghochikyan, Anahit, Masliah, Eliezer, Agadjanyan, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748802/
https://www.ncbi.nlm.nih.gov/pubmed/35013319
http://dx.doi.org/10.1038/s41541-021-00424-2

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