Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance

Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. While prescribed as an inhibitor of DNA replication, 5-FU alters all RNA pathwa...

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Detalles Bibliográficos
Autores principales: Therizols, Gabriel, Bash-Imam, Zeina, Panthu, Baptiste, Machon, Christelle, Vincent, Anne, Ripoll, Julie, Nait-Slimane, Sophie, Chalabi-Dchar, Mounira, Gaucherot, Angéline, Garcia, Maxime, Laforêts, Florian, Marcel, Virginie, Boubaker-Vitre, Jihane, Monet, Marie-Ambre, Bouclier, Céline, Vanbelle, Christophe, Souahlia, Guillaume, Berthel, Elise, Albaret, Marie Alexandra, Mertani, Hichem C., Prudhomme, Michel, Bertrand, Martin, David, Alexandre, Saurin, Jean-Christophe, Bouvet, Philippe, Rivals, Eric, Ohlmann, Théophile, Guitton, Jérôme, Dalla Venezia, Nicole, Pannequin, Julie, Catez, Frédéric, Diaz, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748862/
https://www.ncbi.nlm.nih.gov/pubmed/35013311
http://dx.doi.org/10.1038/s41467-021-27847-8

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