Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Abnormalities in brain glucose metabolism and accumulation of abnormal protein deposits called plaques and tangles are neuropathological hallmarks of Alzheimer’s disease (AD), but their relationship to disease pathogenesis and to each other remains unclear. Here we show that succinylation, a metabol...

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Detalles Bibliográficos
Autores principales: Yang, Yun, Tapias, Victor, Acosta, Diana, Xu, Hui, Chen, Huanlian, Bhawal, Ruchika, Anderson, Elizabeth T., Ivanova, Elena, Lin, Hening, Sagdullaev, Botir T., Chen, Jianer, Klein, William L., Viola, Kirsten L., Gandy, Sam, Haroutunian, Vahram, Beal, M. Flint, Eliezer, David, Zhang, Sheng, Gibson, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748865/
https://www.ncbi.nlm.nih.gov/pubmed/35013160
http://dx.doi.org/10.1038/s41467-021-27572-2

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