Cargando…

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes

A Variant Surface Glycoprotein (VSG) coat protects bloodstream form Trypanosoma brucei. Prodigious amounts of VSG mRNA (~7-10% total) are generated from a single RNA polymerase I (Pol I) transcribed VSG expression site (ES), necessitating extremely high levels of localised splicing. We show that spl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Budzak, James, Jones, Robert, Tschudi, Christian, Kolev, Nikolay G., Rudenko, Gloria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748868/ https://www.ncbi.nlm.nih.gov/pubmed/35013170 http://dx.doi.org/10.1038/s41467-021-27625-6

Ejemplares similares

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes
por: Budzak, James, et al.
Publicado: (2022)

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control
por: Glover, Lucy, et al.
Publicado: (2013)

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei
por: Budzak, James, et al.
Publicado: (2019)

Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes
por: Wang, Qiao-Ping, et al.
Publicado: (2010)

Cohesin regulates VSG monoallelic expression in trypanosomes
por: Landeira, David, et al.
Publicado: (2009)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat
por: Pinger, Jason, et al.
Publicado: (2018)

The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes
por: Schwede, Angela, et al.
Publicado: (2011)

How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?
por: Schwede, Angela, et al.
Publicado: (2015)

FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2014)

NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei
por: Narayanan, Mani Shankar, et al.
Publicado: (2011)

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome
por: Glover, Lucy, et al.
Publicado: (2014)

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei
por: Povelones, Megan L., et al.
Publicado: (2012)

The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2010)

Isolation and analysis of the genetic diversity of repertoires of VSG expression site containing telomeres from Trypanosoma brucei gambiense, T. b. brucei and T. equiperdum
por: Young, Rosanna, et al.
Publicado: (2008)

The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane
por: Hartel, Andreas J. W., et al.
Publicado: (2015)

High Affinity Nanobodies against the Trypanosome brucei VSG Are Potent Trypanolytic Agents that Block Endocytosis
por: Stijlemans, Benoît, et al.
Publicado: (2011)

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites
por: Liu, Dianbo, et al.
Publicado: (2018)

How to create coats for all seasons: elucidating antigenic variation in African trypanosomes
por: Ooi, Cher-Pheng, et al.
Publicado: (2017)

TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomes
por: Narayanan, Mani Shankar, et al.
Publicado: (2013)

VSG mRNA levels are regulated by the production of functional VSG protein
por: Maudlin, Isabella E., et al.
Publicado: (2021)

Do trypanosome turncoats wait before they commit?
por: Ooi, Cher-Pheng, et al.
Publicado: (2014)

A nuclear enterprise: zooming in on nuclear organization and gene expression control in the African trypanosome
por: Faria, Joana R. C.
Publicado: (2021)

Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei
por: Landeira, David, et al.
Publicado: (2007)

Assembling the components of the quorum sensing pathway in African trypanosomes
por: Mony, Binny M, et al.
Publicado: (2015)

African trypanosomes
por: Cayla, Mathieu, et al.
Publicado: (2019)

Well-positioned nucleosomes punctuate polycistronic pol II transcription units and flank silent VSG gene arrays in Trypanosoma brucei
por: Maree, Johannes Petrus, et al.
Publicado: (2017)

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity
por: Cordon-Obras, Carlos, et al.
Publicado: (2013)

TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes
por: Reis, Helena, et al.
Publicado: (2018)

Imaging African trypanosomes
por: MacLean, L, et al.
Publicado: (2013)

Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis
por: Moreno, Cláudia Jassica Gonçalves, et al.
Publicado: (2019)

Life and times: synthesis, trafficking, and evolution of VSG
por: Manna, Paul T., et al.
Publicado: (2014)

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei
por: Kim, Hee-Sook, et al.
Publicado: (2010)

Social Motility in African Trypanosomes
por: Oberholzer, Michael, et al.
Publicado: (2010)

Antigenic variation in African trypanosomes
por: Horn, David
Publicado: (2014)

An Alternative Model for the Role of RP2 Protein in Flagellum Assembly in the African Trypanosome
por: Andre, Jane, et al.
Publicado: (2014)

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis
por: Kerry, Louise E., et al.
Publicado: (2017)

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes
por: Hutchinson, Sebastian, et al.
Publicado: (2016)

Early Invasion of Brain Parenchyma by African Trypanosomes
por: Frevert, Ute, et al.
Publicado: (2012)

The Killing of African Trypanosomes by Ethidium Bromide
por: Roy Chowdhury, Arnab, et al.
Publicado: (2010)

Cell–cell communication in African trypanosomes
por: McWilliam, K. R.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p1hr90be58cv7oqs0unh5rnhf2