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Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states

Eukaryotic topoisomerases I (TOP1) are ubiquitous enzymes removing DNA torsional stress. However, there is little data concerning the three-dimensional structure of TOP1 in the absence of DNA, nor how the DNA molecule can enter/exit its closed conformation. Here, we solved the structure of thermosta...

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Detalles Bibliográficos
Autores principales:	Takahashi, Diane T., Gadelle, Danièle, Agama, Keli, Kiselev, Evgeny, Zhang, Hongliang, Yab, Emilie, Petrella, Stephanie, Forterre, Patrick, Pommier, Yves, Mayer, Claudine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748870/ https://www.ncbi.nlm.nih.gov/pubmed/35013228 http://dx.doi.org/10.1038/s41467-021-27686-7

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