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Targeted editing and evolution of engineered ribosomes in vivo by filtered editing

Genome editing technologies introduce targeted chromosomal modifications in organisms yet are constrained by the inability to selectively modify repetitive genetic elements. Here we describe filtered editing, a genome editing method that embeds group 1 self-splicing introns into repetitive genetic e...

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Detalles Bibliográficos
Autores principales: Radford, Felix, Elliott, Shane D., Schepartz, Alanna, Isaacs, Farren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748908/
https://www.ncbi.nlm.nih.gov/pubmed/35013328
http://dx.doi.org/10.1038/s41467-021-27836-x