Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract

Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. While the intestinal toxicities of TCS require the presence of gut microbiota, the molecular mechanis...

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Detalles Bibliográficos
Autores principales: Zhang, Jianan, Walker, Morgan E., Sanidad, Katherine Z., Zhang, Hongna, Liang, Yanshan, Zhao, Ermin, Chacon-Vargas, Katherine, Yeliseyev, Vladimir, Parsonnet, Julie, Haggerty, Thomas D., Wang, Guangqiang, Simpson, Joshua B., Jariwala, Parth B., Beaty, Violet V., Yang, Jun, Yang, Haixia, Panigrahy, Anand, Minter, Lisa M., Kim, Daeyoung, Gibbons, John G., Liu, LinShu, Li, Zhengze, Xiao, Hang, Borlandelli, Valentina, Overkleeft, Hermen S., Cloer, Erica W., Major, Michael B., Goldfarb, Dennis, Cai, Zongwei, Redinbo, Matthew R., Zhang, Guodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748916/
https://www.ncbi.nlm.nih.gov/pubmed/35013263
http://dx.doi.org/10.1038/s41467-021-27762-y

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