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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

T cells recognize mycobacterial glycolipid (mycolipid) antigens presented by CD1b molecules, but the role of CD4 and CD8 co-receptors in mycolipid recognition is unknown. Here we show CD1b-mycolipid tetramers reveal a hierarchy in which circulating T cells expressing CD4 or CD8 co-receptor stain wit...

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Detalles Bibliográficos
Autores principales:	James, Charlotte A., Xu, Yuexin, Aguilar, Melissa S., Jing, Lichen, Layton, Erik D., Gilleron, Martine, Minnaard, Adriaan J., Scriba, Thomas J., Day, Cheryl L., Warren, Edus H., Koelle, David M., Seshadri, Chetan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748927/ https://www.ncbi.nlm.nih.gov/pubmed/35013257 http://dx.doi.org/10.1038/s41467-021-27764-w

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