Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy

The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of pro- and antiapoptotic Bcl-2 proteins. BH3 mimetics neutralize the antiapoptotic function of Bcl-2 proteins and are highly promising compounds inducing ap...

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Detalles Bibliográficos
Autores principales: Särchen, Vinzenz, Shanmugalingam, Senthan, Kehr, Sarah, Reindl, Lisa Marie, Greze, Victoria, Wiedemann, Sara, Boedicker, Cathinka, Jacob, Maureen, Bankov, Katrin, Becker, Nina, Wehner, Sibylle, Theilen, Till M., Gretser, Steffen, Gradhand, Elise, Kummerow, Carsten, Ullrich, Evelyn, Vogler, Meike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748928/
https://www.ncbi.nlm.nih.gov/pubmed/35013156
http://dx.doi.org/10.1038/s41420-021-00812-6

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