Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

Immune evasion is indispensable for cancer initiation and progression, although its underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known. Here, we characterize the function of tumor-derived PGRN in promoting immune evasion in primary PDAC. Tumor- but not macrophage-de...

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Detalles Bibliográficos
Autores principales: Cheung, Phyllis F., Yang, JiaJin, Fang, Rui, Borgers, Arianna, Krengel, Kirsten, Stoffel, Anne, Althoff, Kristina, Yip, Chi Wai, Siu, Elaine H. L., Ng, Linda W. C., Lang, Karl S., Cham, Lamin B., Engel, Daniel R., Soun, Camille, Cima, Igor, Scheffler, Björn, Striefler, Jana K., Sinn, Marianne, Bahra, Marcus, Pelzer, Uwe, Oettle, Helmut, Markus, Peter, Smeets, Esther M. M., Aarntzen, Erik H. J. G., Savvatakis, Konstantinos, Liffers, Sven-Thorsten, Lueong, Smiths S., Neander, Christian, Bazarna, Anna, Zhang, Xin, Paschen, Annette, Crawford, Howard C., Chan, Anthony W. H., Cheung, Siu Tim, Siveke, Jens T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748938/
https://www.ncbi.nlm.nih.gov/pubmed/35013174
http://dx.doi.org/10.1038/s41467-021-27088-9

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