Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we show that lipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial β-oxidation. Specifically, genetic or pharmacological...

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Detalles Bibliográficos
Autores principales: Misheva, Mariya, Kotzamanis, Konstantinos, Davies, Luke C., Tyrrell, Victoria J., Rodrigues, Patricia R. S., Benavides, Gloria A., Hinz, Christine, Murphy, Robert C., Kennedy, Paul, Taylor, Philip R., Rosas, Marcela, Jones, Simon A., McLaren, James E., Deshpande, Sumukh, Andrews, Robert, Schebb, Nils Helge, Czubala, Magdalena A., Gurney, Mark, Aldrovandi, Maceler, Meckelmann, Sven W., Ghazal, Peter, Darley-Usmar, Victor, White, Daniel A., O’Donnell, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748967/
https://www.ncbi.nlm.nih.gov/pubmed/35013270
http://dx.doi.org/10.1038/s41467-021-27766-8

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