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Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study
INTRODUCTION: Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function. We test...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748969/ https://www.ncbi.nlm.nih.gov/pubmed/35013093 http://dx.doi.org/10.1038/s41387-021-00180-1 |
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author | Pecoraro, Luca Zoller, Thomas Atkinson, Richard L. Nisi, Fulvio Antoniazzi, Franco Cavarzere, Paolo Piacentini, Giorgio Pietrobelli, Angelo |
author_facet | Pecoraro, Luca Zoller, Thomas Atkinson, Richard L. Nisi, Fulvio Antoniazzi, Franco Cavarzere, Paolo Piacentini, Giorgio Pietrobelli, Angelo |
author_sort | Pecoraro, Luca |
collection | PubMed |
description | INTRODUCTION: Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function. We test, among overweight and obese pediatric subjects, the effects on the endothelium of a combination of curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D. METHODS: Forty-eight subjects (6–17 years) were randomized into two groups (placebo vs treatment) attended three visits at 0, 3, and 6 months (±15 days). Endothelial function was assessed by means of a post-occlusive release hyperemic (PORH) test for estimation of delta flow (DF) and hyperemic AUC index, and a heat provocation test (HPT) to measure DF HPT (DF(HPT)). RESULTS: Significant DF difference was noted at 6 months in both groups (p < 0.001). Overall time trend was significantly different between baseline, 3 months, and 6 months both in placebo (p < 0.05) and treatment (p < 0.001) groups and their comparison (p < 0.001). No differences were noted in hyperemic AUC index (3 and 6 months), whilst there were significant differences in time trends of rreatment (p < 0.001) and placebo (p < 0.05) groups and their comparison (p < 0.001). DF(HPT) difference between groups was significant at 3 and 6 months (p < 0.05). The overall time trend was significant exclusively in Treatment group between 3 and 6 months (p < 0.05). Correlation with anthropometrics was found for DF and body mass index (r = 0.677 6 months, p < 0.05), as well as for hyperemic AUC index and males (r = 0.348, p < 0.05), while DF(HPT) showed no correlation. CONCLUSION: Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D appear to be promising in enhancing endothelial function by improvement of both DF in the PORH test and DF in the HPT, lowering the risk of developing cardiovascular diseases in overweight and obese pediatric subjects. |
format | Online Article Text |
id | pubmed-8748969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87489692022-01-20 Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study Pecoraro, Luca Zoller, Thomas Atkinson, Richard L. Nisi, Fulvio Antoniazzi, Franco Cavarzere, Paolo Piacentini, Giorgio Pietrobelli, Angelo Nutr Diabetes Article INTRODUCTION: Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function. We test, among overweight and obese pediatric subjects, the effects on the endothelium of a combination of curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D. METHODS: Forty-eight subjects (6–17 years) were randomized into two groups (placebo vs treatment) attended three visits at 0, 3, and 6 months (±15 days). Endothelial function was assessed by means of a post-occlusive release hyperemic (PORH) test for estimation of delta flow (DF) and hyperemic AUC index, and a heat provocation test (HPT) to measure DF HPT (DF(HPT)). RESULTS: Significant DF difference was noted at 6 months in both groups (p < 0.001). Overall time trend was significantly different between baseline, 3 months, and 6 months both in placebo (p < 0.05) and treatment (p < 0.001) groups and their comparison (p < 0.001). No differences were noted in hyperemic AUC index (3 and 6 months), whilst there were significant differences in time trends of rreatment (p < 0.001) and placebo (p < 0.05) groups and their comparison (p < 0.001). DF(HPT) difference between groups was significant at 3 and 6 months (p < 0.05). The overall time trend was significant exclusively in Treatment group between 3 and 6 months (p < 0.05). Correlation with anthropometrics was found for DF and body mass index (r = 0.677 6 months, p < 0.05), as well as for hyperemic AUC index and males (r = 0.348, p < 0.05), while DF(HPT) showed no correlation. CONCLUSION: Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D appear to be promising in enhancing endothelial function by improvement of both DF in the PORH test and DF in the HPT, lowering the risk of developing cardiovascular diseases in overweight and obese pediatric subjects. Nature Publishing Group UK 2022-01-10 /pmc/articles/PMC8748969/ /pubmed/35013093 http://dx.doi.org/10.1038/s41387-021-00180-1 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Pecoraro, Luca Zoller, Thomas Atkinson, Richard L. Nisi, Fulvio Antoniazzi, Franco Cavarzere, Paolo Piacentini, Giorgio Pietrobelli, Angelo Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title_full | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title_fullStr | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title_full_unstemmed | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title_short | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
title_sort | supportive treatment of vascular dysfunction in pediatric subjects with obesity: the obelix study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748969/ https://www.ncbi.nlm.nih.gov/pubmed/35013093 http://dx.doi.org/10.1038/s41387-021-00180-1 |
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