Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and MAPT(P301S) tauopathy mice revealed that only Aß influenced expression of AD risk genes, but both pathologies precocious...

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Detalles Bibliográficos
Autores principales: Jiwaji, Zoeb, Tiwari, Sachin S., Avilés-Reyes, Rolando X., Hooley, Monique, Hampton, David, Torvell, Megan, Johnson, Delinda A., McQueen, Jamie, Baxter, Paul, Sabari-Sankar, Kayalvizhi, Qiu, Jing, He, Xin, Fowler, Jill, Febery, James, Gregory, Jenna, Rose, Jamie, Tulloch, Jane, Loan, Jamie, Story, David, McDade, Karina, Smith, Amy M., Greer, Peta, Ball, Matthew, Kind, Peter C., Matthews, Paul M., Smith, Colin, Dando, Owen, Spires-Jones, Tara L., Johnson, Jeffrey A., Chandran, Siddharthan, Hardingham, Giles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748982/
https://www.ncbi.nlm.nih.gov/pubmed/35013236
http://dx.doi.org/10.1038/s41467-021-27702-w

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