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Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

Type I interferons (IFNs) are critical for anti-viral responses, and also drive autoimmunity when dysregulated. Upon viral sensing, monocytes elicit a sequential cascade of IFNβ and IFNα production involving feedback amplification, but how exactly this cascade is regulated in human cells is incomple...

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Detalles Bibliográficos
Autores principales:	Gu, Lili, Casserly, David, Brady, Gareth, Carpenter, Susan, Bracken, Adrian P., Fitzgerald, Katherine A., Unterholzner, Leonie, Bowie, Andrew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748983/ https://www.ncbi.nlm.nih.gov/pubmed/35013241 http://dx.doi.org/10.1038/s41467-021-27701-x

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