Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report

A 75-year-old woman who had been taking methotrexate presented to our hospital for fever and dry cough. Chest computed tomography showed ground-glass opacity in the upper lobe of the right lung and foreign bodies in the lower lobe of the right bronchus. During bronchoscopy, foreign bodies were remov...

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Autores principales: Sakuranaka, Haruyasu, Nakagawa, Takashi, Yokota, Shun, Takahashi, Eichi, Yamakawa, Yuji, Hirata, Akifumi, Igei, Koumei, Okamoto, Naoki, Ichioka, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749056/
https://www.ncbi.nlm.nih.gov/pubmed/35036304
http://dx.doi.org/10.1016/j.rmcr.2021.101573
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author Sakuranaka, Haruyasu
Nakagawa, Takashi
Yokota, Shun
Takahashi, Eichi
Yamakawa, Yuji
Hirata, Akifumi
Igei, Koumei
Okamoto, Naoki
Ichioka, Masahiko
author_facet Sakuranaka, Haruyasu
Nakagawa, Takashi
Yokota, Shun
Takahashi, Eichi
Yamakawa, Yuji
Hirata, Akifumi
Igei, Koumei
Okamoto, Naoki
Ichioka, Masahiko
author_sort Sakuranaka, Haruyasu
collection PubMed
description A 75-year-old woman who had been taking methotrexate presented to our hospital for fever and dry cough. Chest computed tomography showed ground-glass opacity in the upper lobe of the right lung and foreign bodies in the lower lobe of the right bronchus. During bronchoscopy, foreign bodies were removed from the airway. We found increased levels of lymphocytes and a high CD4/CD8 ratio in the bronchoalveolar lavage fluid. Transbronchial lung biopsy revealed lymphocytic infiltration. Methotrexate was discontinued, and the imaging findings improved. Methotrexate-induced lung injury does occur unilaterally. Foreign bodies in the airway might also trigger unilateral methotrexate-induced lung injury.
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spelling pubmed-87490562022-01-13 Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report Sakuranaka, Haruyasu Nakagawa, Takashi Yokota, Shun Takahashi, Eichi Yamakawa, Yuji Hirata, Akifumi Igei, Koumei Okamoto, Naoki Ichioka, Masahiko Respir Med Case Rep Case Report A 75-year-old woman who had been taking methotrexate presented to our hospital for fever and dry cough. Chest computed tomography showed ground-glass opacity in the upper lobe of the right lung and foreign bodies in the lower lobe of the right bronchus. During bronchoscopy, foreign bodies were removed from the airway. We found increased levels of lymphocytes and a high CD4/CD8 ratio in the bronchoalveolar lavage fluid. Transbronchial lung biopsy revealed lymphocytic infiltration. Methotrexate was discontinued, and the imaging findings improved. Methotrexate-induced lung injury does occur unilaterally. Foreign bodies in the airway might also trigger unilateral methotrexate-induced lung injury. Elsevier 2022-01-01 /pmc/articles/PMC8749056/ /pubmed/35036304 http://dx.doi.org/10.1016/j.rmcr.2021.101573 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakuranaka, Haruyasu
Nakagawa, Takashi
Yokota, Shun
Takahashi, Eichi
Yamakawa, Yuji
Hirata, Akifumi
Igei, Koumei
Okamoto, Naoki
Ichioka, Masahiko
Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title_full Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title_fullStr Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title_full_unstemmed Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title_short Unilateral methotrexate-induced lung injury with foreign bodies in the airway: A case report
title_sort unilateral methotrexate-induced lung injury with foreign bodies in the airway: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749056/
https://www.ncbi.nlm.nih.gov/pubmed/35036304
http://dx.doi.org/10.1016/j.rmcr.2021.101573
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