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Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization

BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the c...

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Autores principales: Zhao, Yuanyuan, Fan, Yang, Wang, Mengru, Yu, Chenguang, Zhou, Mengchen, Jiang, Dan, Du, Dunfeng, Chen, Shanshan, Tu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749067/
https://www.ncbi.nlm.nih.gov/pubmed/35070816
http://dx.doi.org/10.21037/tau-21-899
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author Zhao, Yuanyuan
Fan, Yang
Wang, Mengru
Yu, Chenguang
Zhou, Mengchen
Jiang, Dan
Du, Dunfeng
Chen, Shanshan
Tu, Xin
author_facet Zhao, Yuanyuan
Fan, Yang
Wang, Mengru
Yu, Chenguang
Zhou, Mengchen
Jiang, Dan
Du, Dunfeng
Chen, Shanshan
Tu, Xin
author_sort Zhao, Yuanyuan
collection PubMed
description BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the causality between KSD and cardiovascular diseases including coronary atherosclerosis, hypertension, and cardiomyopathy. METHODS: In the recent study, we performed a bidirectional two-sample MR study using available genome-wide association summary data from the online database MRBASE. We identified genetic variants associated with KSD in one European population from UK Biobank (version 2, n=462,933). Two phenotypes of samples were chosen from the population to define our genetic instrumental variables: (I) samples with the phenotype of kidney stone/ureter stone/bladder stone (ukb-b-8297), and (II) samples with the phenotype of kidney stone surgery/lithotripsy (ukb-b-13537). For cardiovascular diseases, we picked up another independent European population from FinnGen Biobank (n=93,421). We selected the exposure and outcome SNPs and then performed the two-sample MR using R package. RESULTS: After bidirectional causality by two-sample MR, we verified that genetic predisposition to KSD could increase the risk of coronary atherosclerosis (OR: 4.45×1037; SE=±7.80×10(14), P for MR-Egger =0.024) and cardiomyopathy (OR: 5.35×10(13); SE=±7.18×10(6), P for IVW=0.045 for finn-a-I9_CARDMYO, and OR: 3.60×10(25); SE=±3.26×10(12), P for IVW=0.041 for finn-a-I9_CARDMYOOTH) when we used ukb-b-13537 as exposure group. Furthermore, hypertension could increase the risk of KSD (OR: 1.001; SE=±1.00, P for IVW=0.003) when we used ukb-b-8297 as exposure group, without detected pleiotropy bias (P>0.05). CONCLUSIONS: We confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD.
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spelling pubmed-87490672022-01-21 Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization Zhao, Yuanyuan Fan, Yang Wang, Mengru Yu, Chenguang Zhou, Mengchen Jiang, Dan Du, Dunfeng Chen, Shanshan Tu, Xin Transl Androl Urol Original Article BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the causality between KSD and cardiovascular diseases including coronary atherosclerosis, hypertension, and cardiomyopathy. METHODS: In the recent study, we performed a bidirectional two-sample MR study using available genome-wide association summary data from the online database MRBASE. We identified genetic variants associated with KSD in one European population from UK Biobank (version 2, n=462,933). Two phenotypes of samples were chosen from the population to define our genetic instrumental variables: (I) samples with the phenotype of kidney stone/ureter stone/bladder stone (ukb-b-8297), and (II) samples with the phenotype of kidney stone surgery/lithotripsy (ukb-b-13537). For cardiovascular diseases, we picked up another independent European population from FinnGen Biobank (n=93,421). We selected the exposure and outcome SNPs and then performed the two-sample MR using R package. RESULTS: After bidirectional causality by two-sample MR, we verified that genetic predisposition to KSD could increase the risk of coronary atherosclerosis (OR: 4.45×1037; SE=±7.80×10(14), P for MR-Egger =0.024) and cardiomyopathy (OR: 5.35×10(13); SE=±7.18×10(6), P for IVW=0.045 for finn-a-I9_CARDMYO, and OR: 3.60×10(25); SE=±3.26×10(12), P for IVW=0.041 for finn-a-I9_CARDMYOOTH) when we used ukb-b-13537 as exposure group. Furthermore, hypertension could increase the risk of KSD (OR: 1.001; SE=±1.00, P for IVW=0.003) when we used ukb-b-8297 as exposure group, without detected pleiotropy bias (P>0.05). CONCLUSIONS: We confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD. AME Publishing Company 2021-12 /pmc/articles/PMC8749067/ /pubmed/35070816 http://dx.doi.org/10.21037/tau-21-899 Text en 2021 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhao, Yuanyuan
Fan, Yang
Wang, Mengru
Yu, Chenguang
Zhou, Mengchen
Jiang, Dan
Du, Dunfeng
Chen, Shanshan
Tu, Xin
Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title_full Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title_fullStr Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title_full_unstemmed Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title_short Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
title_sort kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749067/
https://www.ncbi.nlm.nih.gov/pubmed/35070816
http://dx.doi.org/10.21037/tau-21-899
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