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Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization
BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749067/ https://www.ncbi.nlm.nih.gov/pubmed/35070816 http://dx.doi.org/10.21037/tau-21-899 |
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author | Zhao, Yuanyuan Fan, Yang Wang, Mengru Yu, Chenguang Zhou, Mengchen Jiang, Dan Du, Dunfeng Chen, Shanshan Tu, Xin |
author_facet | Zhao, Yuanyuan Fan, Yang Wang, Mengru Yu, Chenguang Zhou, Mengchen Jiang, Dan Du, Dunfeng Chen, Shanshan Tu, Xin |
author_sort | Zhao, Yuanyuan |
collection | PubMed |
description | BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the causality between KSD and cardiovascular diseases including coronary atherosclerosis, hypertension, and cardiomyopathy. METHODS: In the recent study, we performed a bidirectional two-sample MR study using available genome-wide association summary data from the online database MRBASE. We identified genetic variants associated with KSD in one European population from UK Biobank (version 2, n=462,933). Two phenotypes of samples were chosen from the population to define our genetic instrumental variables: (I) samples with the phenotype of kidney stone/ureter stone/bladder stone (ukb-b-8297), and (II) samples with the phenotype of kidney stone surgery/lithotripsy (ukb-b-13537). For cardiovascular diseases, we picked up another independent European population from FinnGen Biobank (n=93,421). We selected the exposure and outcome SNPs and then performed the two-sample MR using R package. RESULTS: After bidirectional causality by two-sample MR, we verified that genetic predisposition to KSD could increase the risk of coronary atherosclerosis (OR: 4.45×1037; SE=±7.80×10(14), P for MR-Egger =0.024) and cardiomyopathy (OR: 5.35×10(13); SE=±7.18×10(6), P for IVW=0.045 for finn-a-I9_CARDMYO, and OR: 3.60×10(25); SE=±3.26×10(12), P for IVW=0.041 for finn-a-I9_CARDMYOOTH) when we used ukb-b-13537 as exposure group. Furthermore, hypertension could increase the risk of KSD (OR: 1.001; SE=±1.00, P for IVW=0.003) when we used ukb-b-8297 as exposure group, without detected pleiotropy bias (P>0.05). CONCLUSIONS: We confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD. |
format | Online Article Text |
id | pubmed-8749067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87490672022-01-21 Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization Zhao, Yuanyuan Fan, Yang Wang, Mengru Yu, Chenguang Zhou, Mengchen Jiang, Dan Du, Dunfeng Chen, Shanshan Tu, Xin Transl Androl Urol Original Article BACKGROUND: Kidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the causality between KSD and cardiovascular diseases including coronary atherosclerosis, hypertension, and cardiomyopathy. METHODS: In the recent study, we performed a bidirectional two-sample MR study using available genome-wide association summary data from the online database MRBASE. We identified genetic variants associated with KSD in one European population from UK Biobank (version 2, n=462,933). Two phenotypes of samples were chosen from the population to define our genetic instrumental variables: (I) samples with the phenotype of kidney stone/ureter stone/bladder stone (ukb-b-8297), and (II) samples with the phenotype of kidney stone surgery/lithotripsy (ukb-b-13537). For cardiovascular diseases, we picked up another independent European population from FinnGen Biobank (n=93,421). We selected the exposure and outcome SNPs and then performed the two-sample MR using R package. RESULTS: After bidirectional causality by two-sample MR, we verified that genetic predisposition to KSD could increase the risk of coronary atherosclerosis (OR: 4.45×1037; SE=±7.80×10(14), P for MR-Egger =0.024) and cardiomyopathy (OR: 5.35×10(13); SE=±7.18×10(6), P for IVW=0.045 for finn-a-I9_CARDMYO, and OR: 3.60×10(25); SE=±3.26×10(12), P for IVW=0.041 for finn-a-I9_CARDMYOOTH) when we used ukb-b-13537 as exposure group. Furthermore, hypertension could increase the risk of KSD (OR: 1.001; SE=±1.00, P for IVW=0.003) when we used ukb-b-8297 as exposure group, without detected pleiotropy bias (P>0.05). CONCLUSIONS: We confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD. AME Publishing Company 2021-12 /pmc/articles/PMC8749067/ /pubmed/35070816 http://dx.doi.org/10.21037/tau-21-899 Text en 2021 Translational Andrology and Urology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Zhao, Yuanyuan Fan, Yang Wang, Mengru Yu, Chenguang Zhou, Mengchen Jiang, Dan Du, Dunfeng Chen, Shanshan Tu, Xin Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title | Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title_full | Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title_fullStr | Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title_full_unstemmed | Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title_short | Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
title_sort | kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749067/ https://www.ncbi.nlm.nih.gov/pubmed/35070816 http://dx.doi.org/10.21037/tau-21-899 |
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