Cargando…

Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast

Inositol pyrophosphate (IPP) dynamics govern expression of the fission yeast phosphate homeostasis regulon via their effects on lncRNA-mediated transcription interference. The growth defects (ranging from sickness to lethality) elicited by fission yeast mutations that inactivate IPP pyrophosphatase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schwer, Beate, Garg, Angad, Sanchez, Ana M., Bernstein, Mindy A., Benjamin, Bradley, Shuman, Stewart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749416/ https://www.ncbi.nlm.nih.gov/pubmed/35012333 http://dx.doi.org/10.1128/mbio.03476-21

Ejemplares similares

A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination
por: Garg, Angad, et al.
Publicado: (2020)

Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22
por: Benjamin, Bradley, et al.
Publicado: (2021)

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression
por: Benjamin, Bradley, et al.
Publicado: (2022)

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination
por: Sanchez, Ana M, et al.
Publicado: (2019)

Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States
por: Benjamin, Bradley, et al.
Publicado: (2022)

Transcriptional profiling of fission yeast RNA polymerase II CTD mutants
por: Garg, Angad, et al.
Publicado: (2021)

Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast
por: Sanchez, Ana M., et al.
Publicado: (2023)

Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination
por: Garg, Angad, et al.
Publicado: (2021)

Distinctive structural basis for DNA recognition by the fission yeast Zn(2)Cys(6) transcription factor Pho7 and its role in phosphate homeostasis
por: Garg, Angad, et al.
Publicado: (2018)

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction
por: Pipercevic, Joka, et al.
Publicado: (2023)

Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3′ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72
por: Sanchez, Ana M, et al.
Publicado: (2020)

Defining the DNA Binding Site Recognized by the Fission Yeast Zn(2)Cys(6) Transcription Factor Pho7 and Its Role in Phosphate Homeostasis
por: Schwer, Beate, et al.
Publicado: (2017)

Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis
por: Garg, Angad, et al.
Publicado: (2023)

Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase
por: Sanchez, Ana M., et al.
Publicado: (2023)

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP(8) and the SPX domain of Pho81
por: Chabert, Valentin, et al.
Publicado: (2023)

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
por: Ried, Martina K., et al.
Publicado: (2021)

RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast
por: Schwer, Beate, et al.
Publicado: (2015)

Fission yeast RNA triphosphatase reads an Spt5 CTD code
por: Doamekpor, Selom K., et al.
Publicado: (2015)

Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination
por: Schwer, Beate, et al.
Publicado: (2020)

Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1
por: Schwer, Beate, et al.
Publicado: (2015)

Preparation of Quality Inositol Pyrophosphates
por: Loss, Omar, et al.
Publicado: (2011)

Poly(A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast
por: Sanchez, Ana M., et al.
Publicado: (2018)

Genome-wide mapping of polyadenylation sites in fission yeast reveals widespread alternative polyadenylation
por: Mata, Juan
Publicado: (2013)

Calnexin Regulates Apoptosis Induced by Inositol Starvation in Fission Yeast
por: Guérin, Renée, et al.
Publicado: (2009)

Biosynthesis and possible functions of inositol pyrophosphates in plants
por: Williams, Sarah P., et al.
Publicado: (2015)

A lncRNA-regulated gene expression system with rapid induction kinetics in the fission yeast Schizosaccharomyces pombe
por: Garg, Angad
Publicado: (2020)

The PAF Complex and Prf1/Rtf1 Delineate Distinct Cdk9-Dependent Pathways Regulating Transcription Elongation in Fission Yeast
por: Mbogning, Jean, et al.
Publicado: (2013)

Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
por: Shah, Akruti, et al.
Publicado: (2017)

Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals
por: Lee, Seulgi, et al.
Publicado: (2020)

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
por: Mukherjee, Sandip, et al.
Publicado: (2020)

Affinity enrichment and identification of inositol poly- and pyrophosphate interactomes
por: Furkert, David, et al.
Publicado: (2021)

Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs
por: Hostachy, Sarah, et al.
Publicado: (2023)

Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast
por: Chatterjee, Debashree, et al.
Publicado: (2016)

Structure–function analysis and genetic interactions of the yeast branchpoint binding protein Msl5
por: Chang, Jonathan, et al.
Publicado: (2012)

Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair
por: Jadav, Rathan S., et al.
Publicado: (2013)

Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates
por: Schwer, Beate, et al.
Publicado: (2016)

Structure–function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring
por: Schwer, Beate, et al.
Publicado: (2016)

Inositol Pyrophosphates and Their Unique Metabolic Complexity: Analysis by Gel Electrophoresis
por: Losito, Oriana, et al.
Publicado: (2009)

Analysis of Dictyostelium discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis
por: Pisani, Francesca, et al.
Publicado: (2014)

Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity
por: Kang, Hyun Ah
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k53ko5oaf3sb48qrn0hp47mi19