Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation

Denham Harman’s oxidative damage theory identifies superoxide (O(2)(•−)) radicals as central agents of aging and radiation injury, with Mn(2+)-dependent superoxide dismutase (MnSOD) as the principal O(2)(•−)-scavenger. However, in the radiation-resistant nematode Caenorhabditis elegans, the mitochon...

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Detalles Bibliográficos
Autores principales: Gaidamakova, Elena K., Sharma, Ajay, Matrosova, Vera Y., Grichenko, Olga, Volpe, Robert P., Tkavc, Rok, Conze, Isabel H., Klimenkova, Polina, Balygina, Irina, Horne, William H., Gostinčar, Cene, Chen, Xiao, Makarova, Kira S., Shuryak, Igor, Srinivasan, Chandra, Jackson-Thompson, Belinda, Hoffman, Brian M., Daly, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749422/
https://www.ncbi.nlm.nih.gov/pubmed/35012337
http://dx.doi.org/10.1128/mbio.03394-21

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