Cargando…

The Role of Fatty Acid Metabolism in Drug Tolerance of Mycobacterium tuberculosis

Mycobacterium tuberculosis can cocatabolize a range of carbon sources. Fatty acids are among the carbons available inside the host’s macrophages. Here, we investigated the metabolic changes of the fatty acid-induced dormancy-like state of M. tuberculosis and its involvement in the acquisition of dru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quinonez, Camila G., Lee, Jae Jin, Lim, Juhyeon, Odell, Mark, Lawson, Christopher P., Anyogu, Amararachukwu, Raheem, Saki, Eoh, Hyungjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749430/ https://www.ncbi.nlm.nih.gov/pubmed/35012349 http://dx.doi.org/10.1128/mbio.03559-21

Ejemplares similares

Fatty acid metabolism of Mycobacterium tuberculosis: A double-edged sword
por: Quinonez, Camila G., et al.
Publicado: (2022)

Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis
por: Eoh, Hyungjin, et al.
Publicado: (2022)

Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis
por: Lee, Jae Jin, et al.
Publicado: (2018)

Metabolic anticipation in Mycobacterium tuberculosis
por: Eoh, Hyungjin, et al.
Publicado: (2017)

Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis
por: Lee, Jae Jin, et al.
Publicado: (2019)

Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis of Candida albicans
por: Liboro, Karl, et al.
Publicado: (2021)

Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance
por: Samuels, Amanda N., et al.
Publicado: (2022)

Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis
por: Ganapathy, Uday, et al.
Publicado: (2015)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum
por: Sarathy, Jansy P., et al.
Publicado: (2018)

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis
por: Puckett, Susan, et al.
Publicado: (2014)

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis
por: Evans, Joanna C., et al.
Publicado: (2016)

Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci
por: Ayoola, Moses B., et al.
Publicado: (2022)

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression
por: Woong Park, Sae, et al.
Publicado: (2011)

The Role of Transport Mechanisms in Mycobacterium Tuberculosis Drug Resistance and Tolerance
por: Sarathy, Jansy Passiflora, et al.
Publicado: (2012)

House of cellulose - a new hideout for drug tolerant Mycobacterium tuberculosis
por: Kumar, Ashwani
Publicado: (2016)

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
por: Chakraborty, Poushali, et al.
Publicado: (2021)

Tools to develop antibiotic combinations that target drug tolerance in Mycobacterium tuberculosis
por: Greenstein, Talia, et al.
Publicado: (2023)

Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand
por: Lanni, Alessio, et al.
Publicado: (2023)

Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence
por: Dutta, Noton K., et al.
Publicado: (2019)

SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae
por: Ayoola, Moses B., et al.
Publicado: (2020)

The Role of the Novel Exopolyphosphatase MT0516 in Mycobacterium tuberculosis Drug Tolerance and Persistence
por: Thayil, Seema M., et al.
Publicado: (2011)

Designing of inhibitors against drug tolerant Mycobacterium tuberculosis (H37Rv)
por: Singla, Deepak, et al.
Publicado: (2013)

Tolerance and Persistence to Drugs: A Main Challenge in the Fight Against Mycobacterium tuberculosis
por: Boldrin, Francesca, et al.
Publicado: (2020)

Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance
por: Sebastian, Jees, et al.
Publicado: (2022)

Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
por: Mowbray, Sherry L., et al.
Publicado: (2014)

Drug-Tolerant Mycobacterium tuberculosis Adopt Different Survival Strategies in Alveolar Macrophages of Patients with Pulmonary Tuberculosis
por: Ufimtseva, Elena G., et al.
Publicado: (2023)

Beyond Killing Mycobacterium tuberculosis: Disease Tolerance
por: Divangahi, Maziar, et al.
Publicado: (2018)

Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance
por: Hicks, Nathan D., et al.
Publicado: (2018)

Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
por: Turapov, Obolbek, et al.
Publicado: (2016)

Metabolomic analysis of Mycobacterium tuberculosis reveals metabolic profiles for identification of drug-resistant tuberculosis
por: Chaiyachat, Pratchakan, et al.
Publicado: (2023)

Comparison of Mycobacterium tuberculosis drug susceptibility using solid and liquid culture in Nigeria
por: Lawson, Lovett, et al.
Publicado: (2013)

CinA mediates multidrug tolerance in Mycobacterium tuberculosis
por: Kreutzfeldt, Kaj M., et al.
Publicado: (2022)

Resistance related metabolic pathways for drug target identification in Mycobacterium tuberculosis
por: Cloete, Ruben, et al.
Publicado: (2016)

Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria
por: Ojha, Anil K, et al.
Publicado: (2008)

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis
por: Sambandan, Dhinakaran, et al.
Publicado: (2013)

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
por: Liu, Yancheng, et al.
Publicado: (2016)

The Mycobacterium tuberculosis CRISPR-Associated Cas1 Involves Persistence and Tolerance to Anti-Tubercular Drugs
por: Wei, Jiawei, et al.
Publicado: (2019)

Mesenchymal stem cells offer a drug-tolerant and immune-privileged niche to Mycobacterium tuberculosis
por: Jain, Neharika, et al.
Publicado: (2020)

Mycobacterium Tuberculosis in Spinal Tuberculosis
por: Moon, Myung-Sang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_14076fvg3clqd5opab9nc9hk2b