An adipose lncRAP2-Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs

lncRAP2 is a conserved cytoplasmic lncRNA enriched in adipose tissue and required for adipogenesis. Using purification and in vivo interactome analyses, we show that lncRAP2 forms complexes with proteins that stabilize mRNAs and modulate translation, among them Igf2bp2. Surveying transcriptome-wide...

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Detalles Bibliográficos
Autores principales: Alvarez-Dominguez, Juan R., Winther, Sally, Hansen, Jacob B., Lodish, Harvey F., Knoll, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749451/
https://www.ncbi.nlm.nih.gov/pubmed/35036870
http://dx.doi.org/10.1016/j.isci.2021.103680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749451/
https://www.ncbi.nlm.nih.gov/pubmed/35036870
http://dx.doi.org/10.1016/j.isci.2021.103680

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