Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting

B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U preferentially targeting WRC (W=A/T, R=A/G) hotspots. Downstream mutations at WA Polymer...

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Detalles Bibliográficos
Autores principales: Tang, Catherine, Krantsevich, Artem, MacCarthy, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749460/
https://www.ncbi.nlm.nih.gov/pubmed/35036866
http://dx.doi.org/10.1016/j.isci.2021.103668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749460/
https://www.ncbi.nlm.nih.gov/pubmed/35036866
http://dx.doi.org/10.1016/j.isci.2021.103668

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