Cargando…
Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting
B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U preferentially targeting WRC (W=A/T, R=A/G) hotspots. Downstream mutations at WA Polymer...
Autores principales: | Tang, Catherine, Krantsevich, Artem, MacCarthy, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749460/ https://www.ncbi.nlm.nih.gov/pubmed/35036866 http://dx.doi.org/10.1016/j.isci.2021.103668 |
Ejemplares similares
-
Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots
por: Krantsevich, Artem, et al.
Publicado: (2021) -
A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes
por: Yu, Guojun, et al.
Publicado: (2021) -
Recombinase-Mediated Cassette Exchange as a Novel Method To Study Somatic Hypermutation in Ramos Cells
por: Baughn, Linda B., et al.
Publicado: (2011) -
DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes
por: Maul, Robert W., et al.
Publicado: (2016) -
Tandem Substitutions in Somatic Hypermutation
por: Sepúlveda-Yáñez, Julieta H., et al.
Publicado: (2022)