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Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study

OBJECTIVES: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate postt...

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Autores principales: Yamada, Ryo, Okumura, Satoshi, Kono, Yuji, Miyazaki, Akane, Niwa, Yudai, Ito, Takehiro, Ueda, Sayano, Ishiguro, Tomoya, Yoshinaga, Masataka, Fujiwara, Wakaya, Hayashi, Mutsuharu, Ozaki, Yukio, Saitoh, Eiichi, Izawa, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fujita Medical Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749499/
https://www.ncbi.nlm.nih.gov/pubmed/35111549
http://dx.doi.org/10.20407/fmj.2020-010
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author Yamada, Ryo
Okumura, Satoshi
Kono, Yuji
Miyazaki, Akane
Niwa, Yudai
Ito, Takehiro
Ueda, Sayano
Ishiguro, Tomoya
Yoshinaga, Masataka
Fujiwara, Wakaya
Hayashi, Mutsuharu
Ozaki, Yukio
Saitoh, Eiichi
Izawa, Hideo
author_facet Yamada, Ryo
Okumura, Satoshi
Kono, Yuji
Miyazaki, Akane
Niwa, Yudai
Ito, Takehiro
Ueda, Sayano
Ishiguro, Tomoya
Yoshinaga, Masataka
Fujiwara, Wakaya
Hayashi, Mutsuharu
Ozaki, Yukio
Saitoh, Eiichi
Izawa, Hideo
author_sort Yamada, Ryo
collection PubMed
description OBJECTIVES: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. METHODS: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. RESULTS: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. CONCLUSIONS: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
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spelling pubmed-87494992022-02-01 Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study Yamada, Ryo Okumura, Satoshi Kono, Yuji Miyazaki, Akane Niwa, Yudai Ito, Takehiro Ueda, Sayano Ishiguro, Tomoya Yoshinaga, Masataka Fujiwara, Wakaya Hayashi, Mutsuharu Ozaki, Yukio Saitoh, Eiichi Izawa, Hideo Fujita Med J Original Article OBJECTIVES: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. METHODS: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. RESULTS: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. CONCLUSIONS: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression. Fujita Medical Society 2021 2020-11-13 /pmc/articles/PMC8749499/ /pubmed/35111549 http://dx.doi.org/10.20407/fmj.2020-010 Text en https://creativecommons.org/licenses/by/4.0/This is an Open access article distributed under the Terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Yamada, Ryo
Okumura, Satoshi
Kono, Yuji
Miyazaki, Akane
Niwa, Yudai
Ito, Takehiro
Ueda, Sayano
Ishiguro, Tomoya
Yoshinaga, Masataka
Fujiwara, Wakaya
Hayashi, Mutsuharu
Ozaki, Yukio
Saitoh, Eiichi
Izawa, Hideo
Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title_full Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title_fullStr Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title_full_unstemmed Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title_short Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study
title_sort effect of cardiac rehabilitation on circulating microrna expression in heart failure: a preliminary study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749499/
https://www.ncbi.nlm.nih.gov/pubmed/35111549
http://dx.doi.org/10.20407/fmj.2020-010
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