Cargando…

Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance

SIMPLE SUMMARY: Normal tissue’s morbidity continues to limit the increase in the therapeutic index in radiation therapy. This study explores the potential advantages of combining proton arc therapy and proton minibeam radiation therapy, which have already individually shown a significant normal tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Ortiz, Ramon, De Marzi, Ludovic, Prezado, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749801/
https://www.ncbi.nlm.nih.gov/pubmed/35008280
http://dx.doi.org/10.3390/cancers14010116
_version_ 1784631317049114624
author Ortiz, Ramon
De Marzi, Ludovic
Prezado, Yolanda
author_facet Ortiz, Ramon
De Marzi, Ludovic
Prezado, Yolanda
author_sort Ortiz, Ramon
collection PubMed
description SIMPLE SUMMARY: Normal tissue’s morbidity continues to limit the increase in the therapeutic index in radiation therapy. This study explores the potential advantages of combining proton arc therapy and proton minibeam radiation therapy, which have already individually shown a significant normal tissue’s sparing. This alliance aims to integrate the benefits of those techniques in a single approach. ABSTRACT: (1) Background: Proton Arc Therapy and Proton Minibeam Radiation Therapy are two novel therapeutic approaches with the potential to lower the normal tissue complication probability, widening the therapeutic window for radioresistant tumors. While the benefits of both modalities have been individually evaluated, their combination and its potential advantages are being assessed in this proof-of-concept study for the first time. (2) Methods: Monte Carlo simulations were employed to evaluate the dose and LET distributions in brain tumor irradiations. (3) Results: a net reduction in the dose to normal tissues (up to 90%), and the preservation of the spatial fractionation of the dose were achieved for all configurations evaluated. Additionally, Proton Minibeam Arc Therapy (pMBAT) reduces the volumes exposed to high-dose and high-LET values at expense of increased low-dose and intermediate-LET values. (4) Conclusions: pMBAT enhances the individual benefits of proton minibeams while keeping those of conventional proton arc therapy. These results might facilitate the path towards patients’ treatments since lower peak doses in normal tissues would be needed than in the case of a single array of proton minibeams.
format Online
Article
Text
id pubmed-8749801
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87498012022-01-12 Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance Ortiz, Ramon De Marzi, Ludovic Prezado, Yolanda Cancers (Basel) Article SIMPLE SUMMARY: Normal tissue’s morbidity continues to limit the increase in the therapeutic index in radiation therapy. This study explores the potential advantages of combining proton arc therapy and proton minibeam radiation therapy, which have already individually shown a significant normal tissue’s sparing. This alliance aims to integrate the benefits of those techniques in a single approach. ABSTRACT: (1) Background: Proton Arc Therapy and Proton Minibeam Radiation Therapy are two novel therapeutic approaches with the potential to lower the normal tissue complication probability, widening the therapeutic window for radioresistant tumors. While the benefits of both modalities have been individually evaluated, their combination and its potential advantages are being assessed in this proof-of-concept study for the first time. (2) Methods: Monte Carlo simulations were employed to evaluate the dose and LET distributions in brain tumor irradiations. (3) Results: a net reduction in the dose to normal tissues (up to 90%), and the preservation of the spatial fractionation of the dose were achieved for all configurations evaluated. Additionally, Proton Minibeam Arc Therapy (pMBAT) reduces the volumes exposed to high-dose and high-LET values at expense of increased low-dose and intermediate-LET values. (4) Conclusions: pMBAT enhances the individual benefits of proton minibeams while keeping those of conventional proton arc therapy. These results might facilitate the path towards patients’ treatments since lower peak doses in normal tissues would be needed than in the case of a single array of proton minibeams. MDPI 2021-12-27 /pmc/articles/PMC8749801/ /pubmed/35008280 http://dx.doi.org/10.3390/cancers14010116 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ortiz, Ramon
De Marzi, Ludovic
Prezado, Yolanda
Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title_full Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title_fullStr Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title_full_unstemmed Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title_short Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance
title_sort proton minibeam radiation therapy and arc therapy: proof of concept of a winning alliance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749801/
https://www.ncbi.nlm.nih.gov/pubmed/35008280
http://dx.doi.org/10.3390/cancers14010116
work_keys_str_mv AT ortizramon protonminibeamradiationtherapyandarctherapyproofofconceptofawinningalliance
AT demarziludovic protonminibeamradiationtherapyandarctherapyproofofconceptofawinningalliance
AT prezadoyolanda protonminibeamradiationtherapyandarctherapyproofofconceptofawinningalliance