Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking

SIMPLE SUMMARY: Germline loss of the CDH1 gene is the primary genetic basis for hereditary diffuse gastric cancer, a disease resulting in elevated risk of both diffuse gastric cancer and lobular breast cancer. Current preventative treatment consists of prophylactic total gastrectomy, a therapy with...

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Detalles Bibliográficos
Autores principales: Brew, Tom, Bougen-Zhukov, Nicola, Mitchell, Wilson, Decourtye, Lyvianne, Schulpen, Emily, Nouri, Yasmin, Godwin, Tanis, Guilford, Parry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749886/
https://www.ncbi.nlm.nih.gov/pubmed/35008266
http://dx.doi.org/10.3390/cancers14010102

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