Propargylation of CoQ0 through the Redox Chain Reaction

[Image: see text] An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect of Sc(OTf)(3) and Hantzsch ester. It is suggested to work through the redox chain reaction, which involves hydroquinone and dimeric propargylic moiety intermediates. A broad range of prop...

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Autores principales: Pawlowski, Robert, Stodulski, Maciej, Mlynarski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749960/
https://www.ncbi.nlm.nih.gov/pubmed/34933550
http://dx.doi.org/10.1021/acs.joc.1c02685
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author Pawlowski, Robert
Stodulski, Maciej
Mlynarski, Jacek
author_facet Pawlowski, Robert
Stodulski, Maciej
Mlynarski, Jacek
author_sort Pawlowski, Robert
collection PubMed
description [Image: see text] An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect of Sc(OTf)(3) and Hantzsch ester. It is suggested to work through the redox chain reaction, which involves hydroquinone and dimeric propargylic moiety intermediates. A broad range of propargylic alcohols can be converted into the appropriate derivatives of CoQ0 containing triple bonds in good to excellent yields. The mechanism of the given transformation is also discussed.
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spelling pubmed-87499602022-01-11 Propargylation of CoQ0 through the Redox Chain Reaction Pawlowski, Robert Stodulski, Maciej Mlynarski, Jacek J Org Chem [Image: see text] An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect of Sc(OTf)(3) and Hantzsch ester. It is suggested to work through the redox chain reaction, which involves hydroquinone and dimeric propargylic moiety intermediates. A broad range of propargylic alcohols can be converted into the appropriate derivatives of CoQ0 containing triple bonds in good to excellent yields. The mechanism of the given transformation is also discussed. American Chemical Society 2021-12-21 2022-01-07 /pmc/articles/PMC8749960/ /pubmed/34933550 http://dx.doi.org/10.1021/acs.joc.1c02685 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Pawlowski, Robert
Stodulski, Maciej
Mlynarski, Jacek
Propargylation of CoQ0 through the Redox Chain Reaction
title Propargylation of CoQ0 through the Redox Chain Reaction
title_full Propargylation of CoQ0 through the Redox Chain Reaction
title_fullStr Propargylation of CoQ0 through the Redox Chain Reaction
title_full_unstemmed Propargylation of CoQ0 through the Redox Chain Reaction
title_short Propargylation of CoQ0 through the Redox Chain Reaction
title_sort propargylation of coq0 through the redox chain reaction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749960/
https://www.ncbi.nlm.nih.gov/pubmed/34933550
http://dx.doi.org/10.1021/acs.joc.1c02685
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AT stodulskimaciej propargylationofcoq0throughtheredoxchainreaction
AT mlynarskijacek propargylationofcoq0throughtheredoxchainreaction

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