HIF-Dependent CKB Expression Promotes Breast Cancer Metastasis, Whereas Cyclocreatine Therapy Impairs Cellular Invasion and Improves Chemotherapy Efficacy

SIMPLE SUMMARY: Targeting dysregulated cellular metabolism is a promising avenue to treat metastatic disease. The aim of our study was to identify genes downstream of the hypoxia-inducible factor (HIF)-1 transcription factor that are amenable to therapeutic intervention to treat metastatic breast ca...

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Detalles Bibliográficos
Autores principales: Krutilina, Raisa I., Playa, Hilaire, Brooks, Danielle L., Schwab, Luciana P., Parke, Deanna N., Oluwalana, Damilola, Layman, Douglas R., Fan, Meiyun, Johnson, Daniel L., Yue, Junming, Smallwood, Heather, Seagroves, Tiffany N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749968/
https://www.ncbi.nlm.nih.gov/pubmed/35008190
http://dx.doi.org/10.3390/cancers14010027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749968/
https://www.ncbi.nlm.nih.gov/pubmed/35008190
http://dx.doi.org/10.3390/cancers14010027

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