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The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review

SIMPLE SUMMARY: Formaldehyde is a chemical compound present in many working activities and indoor workplaces. Occupational exposure occurs primarily by inhaling airborne formaldehyde, but it can also be absorbed through the skin or ingested. The International Agency for Research on Cancer (IARC) cla...

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Autores principales: Protano, Carmela, Buomprisco, Giuseppe, Cammalleri, Vittoria, Pocino, Roberta Noemi, Marotta, Daniela, Simonazzi, Stefano, Cardoni, Francesca, Petyx, Marta, Iavicoli, Sergio, Vitali, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749969/
https://www.ncbi.nlm.nih.gov/pubmed/35008329
http://dx.doi.org/10.3390/cancers14010165
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author Protano, Carmela
Buomprisco, Giuseppe
Cammalleri, Vittoria
Pocino, Roberta Noemi
Marotta, Daniela
Simonazzi, Stefano
Cardoni, Francesca
Petyx, Marta
Iavicoli, Sergio
Vitali, Matteo
author_facet Protano, Carmela
Buomprisco, Giuseppe
Cammalleri, Vittoria
Pocino, Roberta Noemi
Marotta, Daniela
Simonazzi, Stefano
Cardoni, Francesca
Petyx, Marta
Iavicoli, Sergio
Vitali, Matteo
author_sort Protano, Carmela
collection PubMed
description SIMPLE SUMMARY: Formaldehyde is a chemical compound present in many working activities and indoor workplaces. Occupational exposure occurs primarily by inhaling airborne formaldehyde, but it can also be absorbed through the skin or ingested. The International Agency for Research on Cancer (IARC) classified formaldehyde as a Group 1 carcinogen for humans in 2004, based on toxicological data and epidemiological evidence obtained in workplaces, all published before that year. Over the last two decades, many new studies in this field have been published, providing updated findings. The aim of the present systematic review was to synthetize the results of epidemiological studies in occupational settings carried out in the last 20 years and to evaluate whether the IARC classification was confirmed by further studies. Our results show that the evidence of correlation between formaldehyde occupational exposure and the occurrence of cancer is limited. ABSTRACT: Background: Formaldehyde, classified as a carcinogen in 2004, as of today is widely used in many work activities. From its classification, further studies were performed to evaluate its carcinogenicity. The aim of the systematic review is to update the evidence on occupational exposure to formaldehyde and cancer onset. Methods: The review, in accordance with the PRISMA statement, includes articles in English reporting original results of studies conducted on workers exposed to formaldehyde, considering all types of cancer, published from 1 January 2000 to 30 July 2021 and selected from the Pubmed and Scopus databases. The studies’ quality was assessed by the Newcastle–Ottawa Scale. Results: A total of 21 articles were included, conducted in different European, American, and Asian countries. The most investigated occupational areas are those characterized by a deliberate use of formaldehyde. Some studies evaluated all types of cancer, whereas others focused on specific sites such as thyroid and respiratory, lymphohematopoietic, or central nervous systems. The results showed weak associations with lung cancer, nasopharyngeal cancer, leukemia, and non-Hodgkin’s lymphoma. Conclusions: The results demonstrate the need for further original studies carried out on representative samples of workers exposed to measured levels of FA. These studies should be designed to reduce the bias due to co-exposure to other carcinogens.
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spelling pubmed-87499692022-01-12 The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review Protano, Carmela Buomprisco, Giuseppe Cammalleri, Vittoria Pocino, Roberta Noemi Marotta, Daniela Simonazzi, Stefano Cardoni, Francesca Petyx, Marta Iavicoli, Sergio Vitali, Matteo Cancers (Basel) Systematic Review SIMPLE SUMMARY: Formaldehyde is a chemical compound present in many working activities and indoor workplaces. Occupational exposure occurs primarily by inhaling airborne formaldehyde, but it can also be absorbed through the skin or ingested. The International Agency for Research on Cancer (IARC) classified formaldehyde as a Group 1 carcinogen for humans in 2004, based on toxicological data and epidemiological evidence obtained in workplaces, all published before that year. Over the last two decades, many new studies in this field have been published, providing updated findings. The aim of the present systematic review was to synthetize the results of epidemiological studies in occupational settings carried out in the last 20 years and to evaluate whether the IARC classification was confirmed by further studies. Our results show that the evidence of correlation between formaldehyde occupational exposure and the occurrence of cancer is limited. ABSTRACT: Background: Formaldehyde, classified as a carcinogen in 2004, as of today is widely used in many work activities. From its classification, further studies were performed to evaluate its carcinogenicity. The aim of the systematic review is to update the evidence on occupational exposure to formaldehyde and cancer onset. Methods: The review, in accordance with the PRISMA statement, includes articles in English reporting original results of studies conducted on workers exposed to formaldehyde, considering all types of cancer, published from 1 January 2000 to 30 July 2021 and selected from the Pubmed and Scopus databases. The studies’ quality was assessed by the Newcastle–Ottawa Scale. Results: A total of 21 articles were included, conducted in different European, American, and Asian countries. The most investigated occupational areas are those characterized by a deliberate use of formaldehyde. Some studies evaluated all types of cancer, whereas others focused on specific sites such as thyroid and respiratory, lymphohematopoietic, or central nervous systems. The results showed weak associations with lung cancer, nasopharyngeal cancer, leukemia, and non-Hodgkin’s lymphoma. Conclusions: The results demonstrate the need for further original studies carried out on representative samples of workers exposed to measured levels of FA. These studies should be designed to reduce the bias due to co-exposure to other carcinogens. MDPI 2021-12-29 /pmc/articles/PMC8749969/ /pubmed/35008329 http://dx.doi.org/10.3390/cancers14010165 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Protano, Carmela
Buomprisco, Giuseppe
Cammalleri, Vittoria
Pocino, Roberta Noemi
Marotta, Daniela
Simonazzi, Stefano
Cardoni, Francesca
Petyx, Marta
Iavicoli, Sergio
Vitali, Matteo
The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title_full The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title_fullStr The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title_full_unstemmed The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title_short The Carcinogenic Effects of Formaldehyde Occupational Exposure: A Systematic Review
title_sort carcinogenic effects of formaldehyde occupational exposure: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749969/
https://www.ncbi.nlm.nih.gov/pubmed/35008329
http://dx.doi.org/10.3390/cancers14010165
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