The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models

In acute lymphoblastic leukemia (ALL), conventional cell lines do not recapitulate the clonal diversity and microenvironment. Orthotopic patient-derived xenograft models (PDX) overcome these limitations and mimic the clinical situation, but molecular stability and engraftment patterns have not yet b...

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Detalles Bibliográficos
Autores principales: Richter, Anna, Roolf, Catrin, Sekora, Anett, Knuebel, Gudrun, Krohn, Saskia, Lange, Sandra, Krebs, Vivien, Schneider, Bjoern, Lakner, Johannes, Wittke, Christoph, Kiefel, Christoph, Jeremias, Irmela, Murua Escobar, Hugo, Vollmar, Brigitte, Junghanss, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750004/
https://www.ncbi.nlm.nih.gov/pubmed/35011712
http://dx.doi.org/10.3390/cells11010150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750004/
https://www.ncbi.nlm.nih.gov/pubmed/35011712
http://dx.doi.org/10.3390/cells11010150

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