Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition

SIMPLE SUMMARY: High-grade serous ovarian cancer (HGSOC) accounts for 70% of all ovarian-cancer-related deaths. Mainstay treatment with platinum-based drugs following surgery results in favorable outcomes in the majority of patients; however, in >80% of cases, the disease relapses with eventual d...

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Detalles Bibliográficos
Autores principales: Subeha, Mahbuba R., Goyeneche, Alicia A., Bustamante, Prisca, Lisio, Michael A., Burnier, Julia V., Telleria, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750028/
https://www.ncbi.nlm.nih.gov/pubmed/35008264
http://dx.doi.org/10.3390/cancers14010099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750028/
https://www.ncbi.nlm.nih.gov/pubmed/35008264
http://dx.doi.org/10.3390/cancers14010099

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