Cargando…

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex. However, a key player in the developing brain, the microglia, do not natively emerge in cerebral organoids. Here we show that erythromyeloid proge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fagerlund, Ilkka, Dougalis, Antonios, Shakirzyanova, Anastasia, Gómez-Budia, Mireia, Pelkonen, Anssi, Konttinen, Henna, Ohtonen, Sohvi, Fazaludeen, Mohammad Feroze, Koskuvi, Marja, Kuusisto, Johanna, Hernández, Damián, Pebay, Alice, Koistinaho, Jari, Rauramaa, Tuomas, Lehtonen, Šárka, Korhonen, Paula, Malm, Tarja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750120/ https://www.ncbi.nlm.nih.gov/pubmed/35011686 http://dx.doi.org/10.3390/cells11010124

Ejemplares similares

Functional Characterization of Human Pluripotent Stem Cell-Derived Models of the Brain with Microelectrode Arrays
por: Pelkonen, Anssi, et al.
Publicado: (2021)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
por: Konttinen, Henna, et al.
Publicado: (2019)

Metabolic alterations in Parkinson’s disease astrocytes
por: Sonninen, Tuuli-Maria, et al.
Publicado: (2020)

Aβ and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aβ-Laden Environment
por: Savchenko, Ekaterina, et al.
Publicado: (2016)

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis
por: Korhonen, Paula, et al.
Publicado: (2019)

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
por: Malm, Tarja, et al.
Publicado: (2011)

Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer's Disease?
por: Koistinaho, Jari, et al.
Publicado: (2011)

Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
por: Malm, Tarja, et al.
Publicado: (2012)

Production of monocytic cells from bone marrow stem cells: therapeutic usage in Alzheimer’s disease
por: Magga, Johanna, et al.
Publicado: (2012)

Correction: Neurobiological roots of psychopathy
por: Tiihonen, Jari, et al.
Publicado: (2019)

Neurobiological roots of psychopathy
por: Tiihonen, Jari, et al.
Publicado: (2019)

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
por: Keuters, Meike Hedwig, et al.
Publicado: (2021)

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs
por: Wurm, Johannes, et al.
Publicado: (2021)

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
por: Liddell, Jeffrey R., et al.
Publicado: (2016)

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
por: Byts, Nadiya, et al.
Publicado: (2022)

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway
por: Kanninen, Katja, et al.
Publicado: (2011)

Dysfunction of Cellular Proteostasis in Parkinson’s Disease
por: Lehtonen, Šárka, et al.
Publicado: (2019)

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
por: Savchenko, Ekaterina, et al.
Publicado: (2017)

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
por: Sonninen, Tuuli-Maria, et al.
Publicado: (2020)

Blood–Brain Barrier and Neurodegenerative Diseases—Modeling with iPSC-Derived Brain Cells
por: Wu, Ying-Chieh, et al.
Publicado: (2021)

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
por: Koivumäki, Jussi T., et al.
Publicado: (2018)

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease
por: Puli, Lakshman, et al.
Publicado: (2012)

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
por: Jäntti, Henna, et al.
Publicado: (2022)

NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes
por: Oksanen, Minna, et al.
Publicado: (2019)

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
por: Puris, Elena, et al.
Publicado: (2021)

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
por: Oksanen, Minna, et al.
Publicado: (2019)

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases
por: Goldsteins, Gundars, et al.
Publicado: (2022)

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
por: Gynther, Mikko, et al.
Publicado: (2022)

Sex-specific transcriptional and proteomic signatures in schizophrenia
por: Tiihonen, Jari, et al.
Publicado: (2019)

Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS
por: Naumenko, Nikolay, et al.
Publicado: (2011)

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease
por: Magga, Johanna, et al.
Publicado: (2010)

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
por: Kettunen, Pinja, et al.
Publicado: (2023)

Lack of collagen XV is protective after ischemic stroke in mice
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
por: Dhungana, Hiramani, et al.
Publicado: (2013)

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke
por: Kolosowska, Natalia, et al.
Publicado: (2019)

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia
por: Koskuvi, Marja, et al.
Publicado: (2021)

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
por: Dhungana, Hiramani, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k5i8vqdpeo2tqlkkij4fusuomu