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Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication

Bone mass density (BMD) has been used universally in osteoporosis diagnosis and management. Adherence to anti-osteoporosis medication is related to mortality risk. This study aimed to investigate the relationship between mortality and low BMD of the femoral neck and vertebra among patients self-disc...

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Autores principales: Hsu, Chun-Sheng, Chang, Shin-Tsu, Cheng, Yuan-Yang, Lee, Hsu-Tung, Chen, Chih-Hui, Deng, Ya-Lian, Hsu, Chiann-Yi, Chen, Yi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750269/
https://www.ncbi.nlm.nih.gov/pubmed/35010457
http://dx.doi.org/10.3390/ijerph19010197
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author Hsu, Chun-Sheng
Chang, Shin-Tsu
Cheng, Yuan-Yang
Lee, Hsu-Tung
Chen, Chih-Hui
Deng, Ya-Lian
Hsu, Chiann-Yi
Chen, Yi-Ming
author_facet Hsu, Chun-Sheng
Chang, Shin-Tsu
Cheng, Yuan-Yang
Lee, Hsu-Tung
Chen, Chih-Hui
Deng, Ya-Lian
Hsu, Chiann-Yi
Chen, Yi-Ming
author_sort Hsu, Chun-Sheng
collection PubMed
description Bone mass density (BMD) has been used universally in osteoporosis diagnosis and management. Adherence to anti-osteoporosis medication is related to mortality risk. This study aimed to investigate the relationship between mortality and low BMD of the femoral neck and vertebra among patients self-discontinuing anti-osteoporosis medication. Between June 2016 and June 2018, this single-center retrospective study recruited 596 participants who self-discontinued anti-osteoporosis medication. Patients were categorized into four groups by BMD of the right femoral neck and lumbar spine. Occurrence and causes of mortality were obtained from medical records. Independent risk factors and the five-year survival of various levels of BMD were analyzed by Cox regression and the Kaplan–Meier survival analysis. BMD value and serum calcium level were significantly lower in the mortality group (p < 0.001). Compared to the reference, the adjusted hazard ratio (HR) for all-cause mortality in patients with lower BMD of both the lumbar spine and femoral neck was 3.03. The five-year cumulative survival rate was also significantly lower (25.2%, p < 0.001). A low calcium level was also associated with mortality (HR: 0.87, 95% CI: 0.76–0.99, p = 0.033). In conclusion, lower BMD and calcium levels were associated with higher mortality risk in patients with poor adherence. Hence, patients self-discontinuing anti-osteoporosis medication should be managed accordingly.
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spelling pubmed-87502692022-01-12 Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication Hsu, Chun-Sheng Chang, Shin-Tsu Cheng, Yuan-Yang Lee, Hsu-Tung Chen, Chih-Hui Deng, Ya-Lian Hsu, Chiann-Yi Chen, Yi-Ming Int J Environ Res Public Health Article Bone mass density (BMD) has been used universally in osteoporosis diagnosis and management. Adherence to anti-osteoporosis medication is related to mortality risk. This study aimed to investigate the relationship between mortality and low BMD of the femoral neck and vertebra among patients self-discontinuing anti-osteoporosis medication. Between June 2016 and June 2018, this single-center retrospective study recruited 596 participants who self-discontinued anti-osteoporosis medication. Patients were categorized into four groups by BMD of the right femoral neck and lumbar spine. Occurrence and causes of mortality were obtained from medical records. Independent risk factors and the five-year survival of various levels of BMD were analyzed by Cox regression and the Kaplan–Meier survival analysis. BMD value and serum calcium level were significantly lower in the mortality group (p < 0.001). Compared to the reference, the adjusted hazard ratio (HR) for all-cause mortality in patients with lower BMD of both the lumbar spine and femoral neck was 3.03. The five-year cumulative survival rate was also significantly lower (25.2%, p < 0.001). A low calcium level was also associated with mortality (HR: 0.87, 95% CI: 0.76–0.99, p = 0.033). In conclusion, lower BMD and calcium levels were associated with higher mortality risk in patients with poor adherence. Hence, patients self-discontinuing anti-osteoporosis medication should be managed accordingly. MDPI 2021-12-24 /pmc/articles/PMC8750269/ /pubmed/35010457 http://dx.doi.org/10.3390/ijerph19010197 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Chun-Sheng
Chang, Shin-Tsu
Cheng, Yuan-Yang
Lee, Hsu-Tung
Chen, Chih-Hui
Deng, Ya-Lian
Hsu, Chiann-Yi
Chen, Yi-Ming
Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title_full Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title_fullStr Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title_full_unstemmed Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title_short Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication
title_sort low bone mineral density and calcium levels as risks for mortality in patients with self-discontinuation of anti-osteoporosis medication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750269/
https://www.ncbi.nlm.nih.gov/pubmed/35010457
http://dx.doi.org/10.3390/ijerph19010197
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