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The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints

Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biol...

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Autores principales: Haupt, Sandra, Niedrist, Tobias, Sourij, Harald, Schwarzinger, Stephan, Moser, Othmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/
https://www.ncbi.nlm.nih.gov/pubmed/35011715
http://dx.doi.org/10.3390/cells11010153
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author Haupt, Sandra
Niedrist, Tobias
Sourij, Harald
Schwarzinger, Stephan
Moser, Othmar
author_facet Haupt, Sandra
Niedrist, Tobias
Sourij, Harald
Schwarzinger, Stephan
Moser, Othmar
author_sort Haupt, Sandra
collection PubMed
description Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes.
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spelling pubmed-87502792022-01-12 The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints Haupt, Sandra Niedrist, Tobias Sourij, Harald Schwarzinger, Stephan Moser, Othmar Cells Review Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes. MDPI 2022-01-04 /pmc/articles/PMC8750279/ /pubmed/35011715 http://dx.doi.org/10.3390/cells11010153 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Haupt, Sandra
Niedrist, Tobias
Sourij, Harald
Schwarzinger, Stephan
Moser, Othmar
The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title_full The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title_fullStr The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title_full_unstemmed The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title_short The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
title_sort impact of exercise on telomere length, dna methylation and metabolic footprints
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/
https://www.ncbi.nlm.nih.gov/pubmed/35011715
http://dx.doi.org/10.3390/cells11010153
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