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The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints
Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biol...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/ https://www.ncbi.nlm.nih.gov/pubmed/35011715 http://dx.doi.org/10.3390/cells11010153 |
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author | Haupt, Sandra Niedrist, Tobias Sourij, Harald Schwarzinger, Stephan Moser, Othmar |
author_facet | Haupt, Sandra Niedrist, Tobias Sourij, Harald Schwarzinger, Stephan Moser, Othmar |
author_sort | Haupt, Sandra |
collection | PubMed |
description | Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes. |
format | Online Article Text |
id | pubmed-8750279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87502792022-01-12 The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints Haupt, Sandra Niedrist, Tobias Sourij, Harald Schwarzinger, Stephan Moser, Othmar Cells Review Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes. MDPI 2022-01-04 /pmc/articles/PMC8750279/ /pubmed/35011715 http://dx.doi.org/10.3390/cells11010153 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Haupt, Sandra Niedrist, Tobias Sourij, Harald Schwarzinger, Stephan Moser, Othmar The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title | The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title_full | The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title_fullStr | The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title_full_unstemmed | The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title_short | The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints |
title_sort | impact of exercise on telomere length, dna methylation and metabolic footprints |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750279/ https://www.ncbi.nlm.nih.gov/pubmed/35011715 http://dx.doi.org/10.3390/cells11010153 |
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