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Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging

A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facil...

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Autores principales: Liu, Mengping, Wang, Lin, Lo, Young, Shiu, Simon Chi-Chin, Kinghorn, Andrew B., Tanner, Julian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750369/
https://www.ncbi.nlm.nih.gov/pubmed/35011722
http://dx.doi.org/10.3390/cells11010159
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author Liu, Mengping
Wang, Lin
Lo, Young
Shiu, Simon Chi-Chin
Kinghorn, Andrew B.
Tanner, Julian A.
author_facet Liu, Mengping
Wang, Lin
Lo, Young
Shiu, Simon Chi-Chin
Kinghorn, Andrew B.
Tanner, Julian A.
author_sort Liu, Mengping
collection PubMed
description A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application.
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spelling pubmed-87503692022-01-12 Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging Liu, Mengping Wang, Lin Lo, Young Shiu, Simon Chi-Chin Kinghorn, Andrew B. Tanner, Julian A. Cells Review A wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application. MDPI 2022-01-04 /pmc/articles/PMC8750369/ /pubmed/35011722 http://dx.doi.org/10.3390/cells11010159 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Mengping
Wang, Lin
Lo, Young
Shiu, Simon Chi-Chin
Kinghorn, Andrew B.
Tanner, Julian A.
Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title_full Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title_fullStr Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title_full_unstemmed Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title_short Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
title_sort aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750369/
https://www.ncbi.nlm.nih.gov/pubmed/35011722
http://dx.doi.org/10.3390/cells11010159
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AT shiusimonchichin aptamerenablednanomaterialsfortherapeuticsdrugtargetingandimaging
AT kinghornandrewb aptamerenablednanomaterialsfortherapeuticsdrugtargetingandimaging
AT tannerjuliana aptamerenablednanomaterialsfortherapeuticsdrugtargetingandimaging