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IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer
PURPOSE: To compare participants’ knowledge about gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film. METHODS: Using a randomised cross-over design, at time-point one (T1), women aged 45–75 years without...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750374/ https://www.ncbi.nlm.nih.gov/pubmed/34982321 http://dx.doi.org/10.1007/s10549-021-06491-2 |
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author | Fallowfield, L. J. Farewell, D. Jones, H. May, S. Catt, S. Starkings, R. Jenkins, V. |
author_facet | Fallowfield, L. J. Farewell, D. Jones, H. May, S. Catt, S. Starkings, R. Jenkins, V. |
author_sort | Fallowfield, L. J. |
collection | PubMed |
description | PURPOSE: To compare participants’ knowledge about gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film. METHODS: Using a randomised cross-over design, at time-point one (T1), women aged 45–75 years without breast cancer either read leaflets or watched information films about Oncotype DX or Prosigna tests. Participants answered nine questions assessing knowledge (maximum score 18). Next-day information in the opposite modality was provided and knowledge re-assessed. Additional questions probed which format was easiest to understand, participants’ preferences for film or leaflet and their reasons for these. RESULTS: 120 women participated (60 received OncotypeDX films and leaflets; 60 received the Prosigna versions). T1 mean knowledge scores were higher following film viewing (13.37) compared with that after reading leaflets (9.25) (mean difference 4.1; p < 0.0001; 95% CI 3.2, 5.0). When participants read leaflets first and subsequently viewed films, all increased their scores (mean + 6.08, from T1 of 9.25, p < 0.0001; 95% CI 5.44, 6.72). When films were viewed first, followed by leaflets, (36/60, 60%), participants’ scores declined (mean-1.55 from T1 of 13.37, p < 0.001; 95% CI -2.32, -0.78). A majority of participants expressed preferences for the films (88/120, 73.3%) irrespective as to whether they described OncotypeDX or Prosigna. Reasons included the clarity, ease of understanding, visual material and reassuring voice-over. CONCLUSION: Discussions between oncologists and patients about recurrence risk results can be challenging. Information leaflets may aid understanding but often employ complex language. Information films significantly improved knowledge and were preferred by participants. |
format | Online Article Text |
id | pubmed-8750374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-87503742022-01-11 IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer Fallowfield, L. J. Farewell, D. Jones, H. May, S. Catt, S. Starkings, R. Jenkins, V. Breast Cancer Res Treat Preclinical Study PURPOSE: To compare participants’ knowledge about gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film. METHODS: Using a randomised cross-over design, at time-point one (T1), women aged 45–75 years without breast cancer either read leaflets or watched information films about Oncotype DX or Prosigna tests. Participants answered nine questions assessing knowledge (maximum score 18). Next-day information in the opposite modality was provided and knowledge re-assessed. Additional questions probed which format was easiest to understand, participants’ preferences for film or leaflet and their reasons for these. RESULTS: 120 women participated (60 received OncotypeDX films and leaflets; 60 received the Prosigna versions). T1 mean knowledge scores were higher following film viewing (13.37) compared with that after reading leaflets (9.25) (mean difference 4.1; p < 0.0001; 95% CI 3.2, 5.0). When participants read leaflets first and subsequently viewed films, all increased their scores (mean + 6.08, from T1 of 9.25, p < 0.0001; 95% CI 5.44, 6.72). When films were viewed first, followed by leaflets, (36/60, 60%), participants’ scores declined (mean-1.55 from T1 of 13.37, p < 0.001; 95% CI -2.32, -0.78). A majority of participants expressed preferences for the films (88/120, 73.3%) irrespective as to whether they described OncotypeDX or Prosigna. Reasons included the clarity, ease of understanding, visual material and reassuring voice-over. CONCLUSION: Discussions between oncologists and patients about recurrence risk results can be challenging. Information leaflets may aid understanding but often employ complex language. Information films significantly improved knowledge and were preferred by participants. Springer US 2022-01-04 2022 /pmc/articles/PMC8750374/ /pubmed/34982321 http://dx.doi.org/10.1007/s10549-021-06491-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Preclinical Study Fallowfield, L. J. Farewell, D. Jones, H. May, S. Catt, S. Starkings, R. Jenkins, V. IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title | IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title_full | IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title_fullStr | IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title_full_unstemmed | IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title_short | IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
title_sort | imparter, phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer |
topic | Preclinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750374/ https://www.ncbi.nlm.nih.gov/pubmed/34982321 http://dx.doi.org/10.1007/s10549-021-06491-2 |
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