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Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study

(1) Objective: This study examined the incidence and risk factors contributing to the progression to diabetes mellitus (DM) in a seven-year follow-up study of non-diabetic National Health Examinees. (2) Methods: For this retrospective observational cohort study, we used two national representative d...

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Autores principales: Hyun, Min Kyung, Park, Jong Heon, Kim, Kyoung Hoon, Ahn, Soon-Ki, Ji, Seon Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750431/
https://www.ncbi.nlm.nih.gov/pubmed/35010384
http://dx.doi.org/10.3390/ijerph19010123
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author Hyun, Min Kyung
Park, Jong Heon
Kim, Kyoung Hoon
Ahn, Soon-Ki
Ji, Seon Mi
author_facet Hyun, Min Kyung
Park, Jong Heon
Kim, Kyoung Hoon
Ahn, Soon-Ki
Ji, Seon Mi
author_sort Hyun, Min Kyung
collection PubMed
description (1) Objective: This study examined the incidence and risk factors contributing to the progression to diabetes mellitus (DM) in a seven-year follow-up study of non-diabetic National Health Examinees. (2) Methods: For this retrospective observational cohort study, we used two national representative databases: the National Health Screening (HEALS) database 2009 and the National Health Insurance Service (NHIS) database 2009–2015. The eligible subjects without DM with blood sugar levels of <126 mg/dL were selected using the HEALS database. The subsequent follow-up and clinical outcomes were evaluated using the NHIS database. Cox proportional hazard regression was applied to examine the effects of the covariates on progression to diabetes. (3) Results: Among those who took part in the national health screening in 2009, 4,205,006 subjects who met the eligibility criteria were selected. Of these, 587,015 were diagnosed with DM during the follow-up by 2015. The incidence of progression from non-diabetes to DM was 14.0%, whereas that from impaired fasting glucose (IFG) to DM was 21.9%. Compared to the normal group, the newly diagnosed DM group was more likely to comprise older, female, currently smoking, and high-risk drinking participants and participants with IFG, hypertension, dyslipidemia, and metabolic syndrome. (4) Conclusions: This epidemiological study in the Republic of Korea found risk factors similar to those of other studies, but the incidence of progression to DM was 22.8 per 1000 person-years, which is higher than that previously reported. Hence, more care is needed to prevent DM.
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spelling pubmed-87504312022-01-12 Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study Hyun, Min Kyung Park, Jong Heon Kim, Kyoung Hoon Ahn, Soon-Ki Ji, Seon Mi Int J Environ Res Public Health Article (1) Objective: This study examined the incidence and risk factors contributing to the progression to diabetes mellitus (DM) in a seven-year follow-up study of non-diabetic National Health Examinees. (2) Methods: For this retrospective observational cohort study, we used two national representative databases: the National Health Screening (HEALS) database 2009 and the National Health Insurance Service (NHIS) database 2009–2015. The eligible subjects without DM with blood sugar levels of <126 mg/dL were selected using the HEALS database. The subsequent follow-up and clinical outcomes were evaluated using the NHIS database. Cox proportional hazard regression was applied to examine the effects of the covariates on progression to diabetes. (3) Results: Among those who took part in the national health screening in 2009, 4,205,006 subjects who met the eligibility criteria were selected. Of these, 587,015 were diagnosed with DM during the follow-up by 2015. The incidence of progression from non-diabetes to DM was 14.0%, whereas that from impaired fasting glucose (IFG) to DM was 21.9%. Compared to the normal group, the newly diagnosed DM group was more likely to comprise older, female, currently smoking, and high-risk drinking participants and participants with IFG, hypertension, dyslipidemia, and metabolic syndrome. (4) Conclusions: This epidemiological study in the Republic of Korea found risk factors similar to those of other studies, but the incidence of progression to DM was 22.8 per 1000 person-years, which is higher than that previously reported. Hence, more care is needed to prevent DM. MDPI 2021-12-23 /pmc/articles/PMC8750431/ /pubmed/35010384 http://dx.doi.org/10.3390/ijerph19010123 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hyun, Min Kyung
Park, Jong Heon
Kim, Kyoung Hoon
Ahn, Soon-Ki
Ji, Seon Mi
Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title_full Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title_fullStr Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title_full_unstemmed Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title_short Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study
title_sort incidence and risk factors for progression to diabetes mellitus: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750431/
https://www.ncbi.nlm.nih.gov/pubmed/35010384
http://dx.doi.org/10.3390/ijerph19010123
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