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Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor

Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell growth and homeostasis, as well as i...

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Autores principales: Ayala, Juan Carlos, Grismaldo, Adriana, Sequeda-Castañeda, Luis Gonzalo, Aristizábal-Pachón, Andrés Felipe, Morales, Ludis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750443/
https://www.ncbi.nlm.nih.gov/pubmed/34943015
http://dx.doi.org/10.3390/antiox10121912
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author Ayala, Juan Carlos
Grismaldo, Adriana
Sequeda-Castañeda, Luis Gonzalo
Aristizábal-Pachón, Andrés Felipe
Morales, Ludis
author_facet Ayala, Juan Carlos
Grismaldo, Adriana
Sequeda-Castañeda, Luis Gonzalo
Aristizábal-Pachón, Andrés Felipe
Morales, Ludis
author_sort Ayala, Juan Carlos
collection PubMed
description Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell growth and homeostasis, as well as in response to metabolic adaptations, autophagy, immunity, differentiation and cell aging, the latter of which is an important characteristic in acute and chronic pathologies. Thus, the measurement of ROS levels of critically ill patients, upon admission, enables a prediction not only of the severity of the inflammatory response, but also of its subsequent potential outcome. The aim of this study was to measure the levels of mitochondrial ROS (superoxide anion) in the peripheral blood lymphocytes within 24 h of admission and correlate them with survival at one year after ICU and hospital discharge. We designed an observational prospective study in 51 critical care patients, in which clinical variables and ROS production were identified and correlated with mortality at 12 months post-ICU hospitalization. Oxidative stress levels, measured as DHE fluorescence, show a positive correlation with increased long-term mortality. In ICU patients the major determinant of survival is oxidative stress, which determines inflammation and outlines the cellular response to inflammatory stimuli.
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spelling pubmed-87504432022-01-12 Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor Ayala, Juan Carlos Grismaldo, Adriana Sequeda-Castañeda, Luis Gonzalo Aristizábal-Pachón, Andrés Felipe Morales, Ludis Antioxidants (Basel) Article Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell growth and homeostasis, as well as in response to metabolic adaptations, autophagy, immunity, differentiation and cell aging, the latter of which is an important characteristic in acute and chronic pathologies. Thus, the measurement of ROS levels of critically ill patients, upon admission, enables a prediction not only of the severity of the inflammatory response, but also of its subsequent potential outcome. The aim of this study was to measure the levels of mitochondrial ROS (superoxide anion) in the peripheral blood lymphocytes within 24 h of admission and correlate them with survival at one year after ICU and hospital discharge. We designed an observational prospective study in 51 critical care patients, in which clinical variables and ROS production were identified and correlated with mortality at 12 months post-ICU hospitalization. Oxidative stress levels, measured as DHE fluorescence, show a positive correlation with increased long-term mortality. In ICU patients the major determinant of survival is oxidative stress, which determines inflammation and outlines the cellular response to inflammatory stimuli. MDPI 2021-11-29 /pmc/articles/PMC8750443/ /pubmed/34943015 http://dx.doi.org/10.3390/antiox10121912 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ayala, Juan Carlos
Grismaldo, Adriana
Sequeda-Castañeda, Luis Gonzalo
Aristizábal-Pachón, Andrés Felipe
Morales, Ludis
Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title_full Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title_fullStr Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title_full_unstemmed Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title_short Oxidative Stress in ICU Patients: ROS as Mortality Long-Term Predictor
title_sort oxidative stress in icu patients: ros as mortality long-term predictor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750443/
https://www.ncbi.nlm.nih.gov/pubmed/34943015
http://dx.doi.org/10.3390/antiox10121912
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