Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue

The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (Ppara(FatKO)) mice t...

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Detalles Bibliográficos
Autores principales: Hinds, Terry D., Kipp, Zachary A., Xu, Mei, Yiannikouris, Frederique B., Morris, Andrew J., Stec, Donald F., Wahli, Walter, Stec, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750478/
https://www.ncbi.nlm.nih.gov/pubmed/35011564
http://dx.doi.org/10.3390/cells11010004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750478/
https://www.ncbi.nlm.nih.gov/pubmed/35011564
http://dx.doi.org/10.3390/cells11010004

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