Cargando…

Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue

The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established the first adipose-specific PPARα knockout (Ppara(FatKO)) mice t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hinds, Terry D., Kipp, Zachary A., Xu, Mei, Yiannikouris, Frederique B., Morris, Andrew J., Stec, Donald F., Wahli, Walter, Stec, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750478/ https://www.ncbi.nlm.nih.gov/pubmed/35011564 http://dx.doi.org/10.3390/cells11010004

Ejemplares similares

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis
por: Li, Qing, et al.
Publicado: (2023)

High phosphate diet suppresses lipogenesis in white adipose tissue
por: Imi, Yukiko, et al.
Publicado: (2018)

Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice
por: Stec, David E., et al.
Publicado: (2020)

Bilirubin Binding to PPARα Inhibits Lipid Accumulation
por: Stec, David E., et al.
Publicado: (2016)

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
por: Zhao, Qiushi, et al.
Publicado: (2022)

Consumption of resistant starch decreases postprandial lipogenesis in white adipose tissue of the rat
por: Higgins, Janine A, et al.
Publicado: (2006)

Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
por: Guilherme, Adilson, et al.
Publicado: (2018)

Regulation of Lipogenesis by Glucocorticoids and Insulin in Human Adipose Tissue
por: Gathercole, Laura L., et al.
Publicado: (2011)

SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction
por: Kobayashi, Masaki, et al.
Publicado: (2018)

Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway
por: Lin, Yen-Chung, et al.
Publicado: (2019)

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila
por: Li, Xiao, et al.
Publicado: (2022)

CD38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating Sirt1/PPARγ signaling pathway
por: Wang, Ling‐Fang, et al.
Publicado: (2017)

Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK
por: Hurtado-Carneiro, Verónica, et al.
Publicado: (2021)

Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice
por: Braud, Laura, et al.
Publicado: (2020)

Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
por: Song, Ziyi, et al.
Publicado: (2018)

PPARs and Adipose Cell Plasticity
por: Casteilla, Louis, et al.
Publicado: (2007)

Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease
por: Stec, David E., et al.
Publicado: (2020)

Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance
por: Kipp, Zachary A., et al.
Publicado: (2023)

ChREBP-regulated lipogenesis is not required for the thermogenesis of brown adipose tissue
por: Wei, Chunchun, et al.
Publicado: (2022)

MED1 is a lipogenesis coactivator required for postnatal adipose expansion
por: Jang, Younghoon, et al.
Publicado: (2021)

Oncogenic signaling upstream of mTORC1 drives lipogenesis and proliferation through SREBP
por: Ricoult, Stéphane, et al.
Publicado: (2014)

Large Yellow Tea Extract Ameliorates Metabolic Syndrome by Suppressing Lipogenesis through SIRT6/SREBP1 Pathway and Modulating Microbiota in Leptin Receptor Knockout Rats
por: Wu, Guohuo, et al.
Publicado: (2022)

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy
por: Talebi, Ali, et al.
Publicado: (2018)

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumor growth
por: Cheng, Chunming, et al.
Publicado: (2022)

Improvement of Adipose Macrophage Polarization in High Fat Diet-Induced Obese GHSR Knockout Mice
por: Yuan, Fang, et al.
Publicado: (2018)

PPARs-Orchestrated Metabolic Homeostasis in the Adipose Tissue
por: Sun, Chen, et al.
Publicado: (2021)

Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
por: Zhang, Dan-dan, et al.
Publicado: (2015)

Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue
por: García-Fuentes, Eduardo, et al.
Publicado: (2015)

Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders
por: Stec, David E., et al.
Publicado: (2021)

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice
por: Linden, Albert G., et al.
Publicado: (2018)

Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c
por: Yao, Jian, et al.
Publicado: (2023)

MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer
por: Tibbo, Amy J., et al.
Publicado: (2023)

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis
por: Kikani, Chintan K, et al.
Publicado: (2016)

Signal-regulated unmasking of the nuclear localization motif in the PAS domain regulates the nuclear translocation of PASK
por: Xiao, Michael, et al.
Publicado: (2023)

Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
por: Semplici, Francesca, et al.
Publicado: (2011)

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate
por: Hinds, Terry D., et al.
Publicado: (2020)

PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
por: Zhong, Yi, et al.
Publicado: (2023)

De Novo Lipogenesis in Adipose Tissue Is Associated with Course of Morbid Obesity after Bariatric Surgery
por: Garrido-Sánchez, Lourdes, et al.
Publicado: (2012)

Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A
por: Shong, Ko Eun, et al.
Publicado: (2020)

Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice
por: Negron, Steven G., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hafmgs8rvpr84k8u594t61c8ri