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Friend or Foe? The Roles of Antioxidants in Acute Lung Injury

Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra- and extra-pulmonary injury factors. The oxidative stress caused by excessive reactive oxygen species (ROS) produced in the lungs plays an important role in the pathogenesis of ALI. ROS is a “double-edged s...

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Autores principales: Liu, Yang, Zhou, Shujun, Xiang, Du, Ju, Lingao, Shen, Dexin, Wang, Xinghuan, Wang, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750496/
https://www.ncbi.nlm.nih.gov/pubmed/34943059
http://dx.doi.org/10.3390/antiox10121956
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author Liu, Yang
Zhou, Shujun
Xiang, Du
Ju, Lingao
Shen, Dexin
Wang, Xinghuan
Wang, Yanfeng
author_facet Liu, Yang
Zhou, Shujun
Xiang, Du
Ju, Lingao
Shen, Dexin
Wang, Xinghuan
Wang, Yanfeng
author_sort Liu, Yang
collection PubMed
description Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra- and extra-pulmonary injury factors. The oxidative stress caused by excessive reactive oxygen species (ROS) produced in the lungs plays an important role in the pathogenesis of ALI. ROS is a “double-edged sword”, which is widely involved in signal transduction and the life process of cells at a physiological concentration. However, excessive ROS can cause mitochondrial oxidative stress, leading to the occurrence of various diseases. It is well-known that antioxidants can alleviate ALI by scavenging ROS. Nevertheless, more and more studies found that antioxidants have no significant effect on severe organ injury, and may even aggravate organ injury and reduce the survival rate of patients. Our study introduces the application of antioxidants in ALI, and explore the mechanisms of antioxidants failure in various diseases including it.
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spelling pubmed-87504962022-01-12 Friend or Foe? The Roles of Antioxidants in Acute Lung Injury Liu, Yang Zhou, Shujun Xiang, Du Ju, Lingao Shen, Dexin Wang, Xinghuan Wang, Yanfeng Antioxidants (Basel) Review Acute lung injury (ALI) is an acute hypoxic respiratory insufficiency caused by various intra- and extra-pulmonary injury factors. The oxidative stress caused by excessive reactive oxygen species (ROS) produced in the lungs plays an important role in the pathogenesis of ALI. ROS is a “double-edged sword”, which is widely involved in signal transduction and the life process of cells at a physiological concentration. However, excessive ROS can cause mitochondrial oxidative stress, leading to the occurrence of various diseases. It is well-known that antioxidants can alleviate ALI by scavenging ROS. Nevertheless, more and more studies found that antioxidants have no significant effect on severe organ injury, and may even aggravate organ injury and reduce the survival rate of patients. Our study introduces the application of antioxidants in ALI, and explore the mechanisms of antioxidants failure in various diseases including it. MDPI 2021-12-07 /pmc/articles/PMC8750496/ /pubmed/34943059 http://dx.doi.org/10.3390/antiox10121956 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yang
Zhou, Shujun
Xiang, Du
Ju, Lingao
Shen, Dexin
Wang, Xinghuan
Wang, Yanfeng
Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title_full Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title_fullStr Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title_full_unstemmed Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title_short Friend or Foe? The Roles of Antioxidants in Acute Lung Injury
title_sort friend or foe? the roles of antioxidants in acute lung injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750496/
https://www.ncbi.nlm.nih.gov/pubmed/34943059
http://dx.doi.org/10.3390/antiox10121956
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